Laboratory of drug sciences, biomedical research, and biotechnology. Faculty of Medicine and Pharmacy, Hassan II University of Casablanca, Morocco.
Laboratory of drug sciences, biomedical research, and biotechnology. Faculty of Medicine and Pharmacy, Hassan II University of Casablanca, Morocco.
J Pharmacol Toxicol Methods. 2023 Sep-Oct;123:107294. doi: 10.1016/j.vascn.2023.107294. Epub 2023 Jul 17.
Benzodiazepines are one of the most widely used classes of drugs around the world. They are medically used in different therapeutic areas including insomnia, anxiety, epilepsy, and anesthesia. Unfortunately, these drugs are very widespread in the illicit market for recreational purposes and cause drug dependence, traffic accidents, and criminality. Furthermore, benzodiazepine misuse leads to acute poisoning cases that often end up in hospital emergency rooms. Therefore, it is crucial for hospitals to possess straightforward and efficient bioanalytical techniques that enable the swift detection of benzodiazepines in biological samples. This review provides a general overview of the different bioanalytical techniques used for the detection and quantification of benzodiazepines in biological samples and emphasizes their suitability for emergency toxicological analyzes.
苯二氮䓬类药物是全球应用最广泛的药物之一。它们在医学上用于包括失眠、焦虑、癫痫和麻醉在内的不同治疗领域。不幸的是，这些药物在娱乐目的的非法市场上非常普遍，会导致药物依赖、交通事故和犯罪。此外，苯二氮䓬类药物的滥用会导致急性中毒病例，这些病例经常出现在医院的急诊室。因此，医院拥有直接有效的生物分析技术来快速检测生物样本中的苯二氮䓬类药物至关重要。本文综述了用于检测和定量生物样本中苯二氮䓬类药物的不同生物分析技术，并强调了它们在紧急毒理学分析中的适用性。
