Diabetes, Endocrinology And Metabolism, Imperial College Healthcare NHS Trust, UK.
Diabetes, Endocrinology And Metabolism, Imperial College Healthcare NHS Trust, UK; Department of Bioengineering, Faculty of Engineering, Imperial College London, London, UK.
Best Pract Res Clin Endocrinol Metab. 2023 Jul;37(4):101793. doi: 10.1016/j.beem.2023.101793. Epub 2023 Jun 28.
The SARS-CoV-2 pandemic has had an unprecedented effect on global health, mortality and healthcare provision. Diabetes has emerged as a key disease entity over the pandemic period, influencing outcomes from COVID-19 but also a tantalising hypothesis that the virus itself may be inducing diabetes. An uptick in diabetes cases over the pandemic has been noted for both type 1 diabetes (in children) and type 2 diabetes but understanding how this increase in incidence relates to the pandemic is challenging. It remains unclear whether indirect effects of the pandemic on behaviour, lifestyle and health have contributed to the increase; whether the virus itself has somehow mediated new-onset diabetes or whether other factors such as stress hyperglycaemic of steroid treatment during COVID-19 infection have played a roll. Within the myriad possibilities are some real challenges in interpreting epidemiological data, assigning diabetes type and understanding what in vitro data are telling us. In this review article we address the issue of newly-diagnosed diabetes during the pandemic, reviewing both epidemiological and basic science data and bringing together both strands of this emerging story.
SARS-CoV-2 大流行对全球健康、死亡率和医疗保健服务产生了前所未有的影响。在大流行期间，糖尿病已成为一个主要疾病实体，不仅影响 COVID-19 的结局，而且还提出了一个诱人的假说，即该病毒本身可能会导致糖尿病。在大流行期间，1 型糖尿病（儿童）和 2 型糖尿病的糖尿病病例均有所增加，但要了解发病率的这种增加与大流行之间的关系具有挑战性。目前尚不清楚大流行对行为、生活方式和健康的间接影响是否导致了这种增加；病毒本身是否以某种方式介导了新发糖尿病，或者 COVID-19 感染期间应激性高血糖或类固醇治疗等其他因素是否发挥了作用。在无数的可能性中，在解释流行病学数据、确定糖尿病类型和理解体外数据告诉我们什么方面存在一些真正的挑战。在这篇综述文章中，我们讨论了大流行期间新诊断出的糖尿病问题，回顾了流行病学和基础科学数据，并将这一新兴故事的两个方面结合在一起。
