Lew V L, Bookchin R M
J Membr Biol. 1986;92(1):57-74. doi: 10.1007/BF01869016.
A basic mathematical model of human red cells is presented which integrates the charge and nonideal osmotic behavior of hemoglobin and of other impermeant cell solutes with the ion transport properties of the red cell membrane. The computing strategy was designed to predict the behavior of all measurable variables in time in ways that optimize comparison with experimentally determined behavior. The need and applications of such a model are illustrated in three separate examples covering different areas of experimentation in the physiology and pathophysiology of red cells.
本文提出了一个人类红细胞的基本数学模型，该模型将血红蛋白和其他非渗透性细胞溶质的电荷及非理想渗透行为与红细胞膜的离子转运特性整合在一起。计算策略的设计目的是以优化与实验测定行为比较的方式预测所有可测量变量随时间的行为。在涵盖红细胞生理学和病理生理学不同实验领域的三个独立示例中说明了这种模型的必要性和应用。
