Department of Medicine, Aga Khan University Hospital, Karachi, Pakistan.
J Pak Med Assoc. 2023 Jul;73(7):1511-1513. doi: 10.47391/JPMA.6271.
Brown tumour is an infrequent, focal, and benign osteolytic lesion which is a consequence of abnormal bone metabolism in hyperparathyroidism (both primary and secondary). It is also known as Osteoclastoma. In the present era, we rarely encounter skeletal disease caused by primary hyperparathyroidism. Although it is a rare presentation because of advancement of treatment but still can be encountered because of lack of standard care so we should have high index of suspicion to avoid this preventable complication. We report here a case of brown tumour in the thoracic vertebra of a young female patient with End Stage Renal Disease, who presented with backache and bilateral lower limb weakness. MRI of the spine showed multiple non 20 enhancing abnormal signals involving vertebral body of C2, posterior elements of C6, and bilateral sacral vertebra, suggestive of healed fractures versus bone forming tumours. She underwent laminectomy. Her histopathology report was consistent with brown tumour of hyperparathyroidism.
棕色瘤是一种不常见的、局灶性的良性溶骨性病变，是甲状旁腺功能亢进（包括原发性和继发性）导致骨代谢异常的结果。它也被称为破骨细胞瘤。在当今时代，我们很少遇到由原发性甲状旁腺功能亢进引起的骨骼疾病。尽管由于治疗的进步，这种情况很少见，但由于缺乏标准的护理，仍然可能会遇到，因此我们应该高度怀疑，以避免这种可预防的并发症。我们在此报告一例年轻女性终末期肾病患者的胸椎棕色瘤病例，该患者表现为背痛和双侧下肢无力。脊柱 MRI 显示多个非增强异常信号，涉及 C2 椎体、C6 后元素和双侧骶骨，提示为愈合性骨折而非成骨肿瘤。她接受了椎板切除术。她的组织病理学报告与甲状旁腺功能亢进的棕色瘤一致。
