Grissom R E, Thaxton J P
J Toxicol Environ Health. 1986;19(1):65-74. doi: 10.1080/15287398609530907.
Four-week-old male chickens were subjected to one of the following treatments: 0 ppm mercury (Hg) plus water ad libitum, 0 ppm Hg plus limited water (LW), 500 ppm Hg plus water ad libitum, and 500 ppm Hg plus LW. Exposure was for each of the following time intervals: 0-3, 0-6, 0-9, 0-12, and 0-15 d. LW significantly increased red blood cell (RBC) numbers, hematocrit (HCT), mean corpuscular volume (MCV), and hemoglobin (Hb) level and significantly decreased mean corpuscular hemoglobin (MCH) level within 3 d of treatment. Mercury produced variable results, with no significant trends developing during the treatment period. The effects caused by Hg appeared to be masked by the effects of dehydration. The birds receiving water ad libitum had numerically greater RBC numbers and HCT and Hb levels than birds receiving water ad libitum that was contaminated with Hg, while the effects caused by Hg in the groups that received limited water were not consistent. Each group was given a recovery period of 14 d, during which time all birds received uncontaminated water and feed ad libitum. The hematologic effects caused by Hg and water deprivation did not return to a normal condition. Reduced RBC numbers, HCT, and Hb levels were observed at the end of the recovery period in the birds that were exposed to Hg and/or water deprivation.
0 ppm汞（Hg）并随意饮水，0 ppm Hg并限量饮水（LW），500 ppm Hg并随意饮水，以及500 ppm Hg并限量饮水。暴露时间为以下每个时间间隔：0 - 3天、0 - 6天、0 - 9天、0 - 12天和0 - 15天。限量饮水在处理3天内显著增加了红细胞（RBC）数量、血细胞比容（HCT）、平均红细胞体积（MCV）和血红蛋白（Hb）水平，并显著降低了平均红细胞血红蛋白（MCH）水平。汞产生了不同的结果，在处理期间没有出现显著趋势。汞引起的影响似乎被脱水的影响所掩盖。随意饮水的鸡的RBC数量、HCT和Hb水平在数值上高于饮用被汞污染的随意饮水的鸡，而在限量饮水组中汞引起的影响并不一致。每组给予14天的恢复期，在此期间所有鸡随意饮用未受污染的水并进食。汞和缺水引起的血液学影响并未恢复到正常状态。在恢复期结束时，暴露于汞和/或缺水的鸡的RBC数量、HCT和Hb水平降低。
