Jeon Daejong, Choi Jiye, Yang Ah Reum, Yoo Jung-Seok, Kim Sangwoo, Lee Sang Kun, Chu Kon
Advanced Neural Technologies, Co., Seoul, Korea.
Korea Advanced Institute of Science and Technology, Daejeon, Korea.
Encephalitis. 2022 Apr;2(2):45-53. doi: 10.47936/encephalitis.2021.00178. Epub 2022 Mar 11.
Chronic social stress is known to induce inflammation in the brain, and early-life stress affects the brain and social behavior in adulthood. To study the relationship between social stress in childhood development and social behavior in adulthood, we subjected mice to a sequential early-life social stresses and characterized their adult behavioral phenotypes.
C57BL/6 mice were sequentially subjected to maternal separation (MS), social defeat (SD), and social isolation (SI) in that order. The body weights of the MS/SD/SI mice were measured. Behavioral tasks related to anxiety, depression, locomotion, learning/memory, and repetitive/compulsive-like behavior were conducted. Social behaviors suggesting sociability, social interaction, aggression, and social fear were investigated.
MS/SD/SI mice weighed less than the control mice. At 7 and 8 weeks of age. These mice displayed normal behaviors in anxiety-, depression-, and learning/memory-related tasks, but they exhibited increased locomotor activity and a low level of repetitive/compulsive-like behavior. Notably, they exhibited increased social interaction, impaired empathy-related fear, reduced predator fear, and increased defensive aggressiveness.
Social stress during childhood development resulted in behavioral alterations, and MS/SD/SI mice generated by mimicking child abuse or maltreatment showed unique abnormalities in social behaviors. MS/SD/SI mice might be useful not only to study the relationship between social stress and brain inflammation but also psychosocial behaviors observed in individuals with brain disorders, such as psychopaths.
已知慢性社会应激会诱发大脑炎症，且早年应激会影响成年期的大脑和社会行为。为了研究儿童发育过程中的社会应激与成年期社会行为之间的关系，我们让小鼠经历一系列早年社会应激，并对它们成年后的行为表型进行了表征。
C57BL/6小鼠按顺序依次经历母婴分离（MS）、社会挫败（SD）和社会隔离（SI）。测量MS/SD/SI小鼠的体重。进行了与焦虑、抑郁、运动、学习/记忆以及重复/强迫样行为相关的行为任务。研究了表明社交性、社会互动、攻击性和社会恐惧的社会行为。
MS/SD/SI小鼠的体重低于对照小鼠。在7周和8周龄时。这些小鼠在与焦虑、抑郁和学习/记忆相关的任务中表现出正常行为，但它们表现出运动活动增加和重复/强迫样行为水平较低。值得注意的是，它们表现出社会互动增加、共情相关恐惧受损、捕食者恐惧降低以及防御性攻击性增加。
儿童发育期间的社会应激导致行为改变，通过模拟虐待或虐待儿童产生的MS/SD/SI小鼠在社会行为方面表现出独特的异常。MS/SD/SI小鼠可能不仅有助于研究社会应激与大脑炎症之间的关系，还有助于研究在患有脑部疾病的个体（如精神病患者）中观察到的社会心理行为。
