预防第三磨牙拔除术后手术部位感染的预防性治疗：综述概述
Prophylactic therapy for prevention of surgical site infection after extraction of third molar: An overview of reviews.
作者信息
Cao Y, Jiang Q, Hu J
机构信息
Department of Oral and Maxillofacial-Head and Neck Oncology Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine Shanghai, 200011, China
出版信息
Med Oral Patol Oral Cir Bucal. 2023 Nov 1;28(6):e581-e587. doi: 10.4317/medoral.25999.
BACKGROUND
To compare the effect of different prophylactic therapies on prevention of surgical site infection after extraction of third molars with different degree of impaction.
MATERIAL AND METHODS
Systematic reviews and meta-analyses evaluating the effect of different prophylactic therapies on prevention of surgical site infection after extraction of third molars were included. An electronic search was performed in PubMed, EMBASE, and the Cochrane Database of Systematic reviews. AMSTAR 2 tool was used to evaluate the confidence in results from the included reviews. Descriptive analyses were performed.
RESULTS
Six reviews were included. A significant benefit of different antibiotics to the prevention of site infection after extraction of third molars was reported. Amoxicillin/amoxicillin clavulanic acid could significantly reduce the rate of surgical site infection versus placebo. Chlorhexidine gel could significantly reduce the frequency of alveolar osteitis versus placebo.
CONCLUSIONS
Based on the limited evidence, there is a significant benefit of prophylactic therapy while the comparative effect of different types of prophylactic regimes are controversial.
背景
比较不同预防性治疗对不同阻生程度的第三磨牙拔除术后手术部位感染预防效果的影响。
材料与方法
纳入评估不同预防性治疗对第三磨牙拔除术后手术部位感染预防效果的系统评价和荟萃分析。在PubMed、EMBASE和Cochrane系统评价数据库中进行电子检索。使用AMSTAR 2工具评估纳入评价结果的可信度。进行描述性分析。
结果
纳入六项评价。报告了不同抗生素对第三磨牙拔除术后手术部位感染预防有显著益处。阿莫西林/阿莫西林克拉维酸与安慰剂相比可显著降低手术部位感染率。氯己定凝胶与安慰剂相比可显著降低牙槽骨炎的发生率。
结论
基于有限的证据，预防性治疗有显著益处，而不同类型预防方案的比较效果存在争议。
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