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Weight gain in patients with RET aberrant cancers treated with brain penetrant RET selective inhibitors.

作者信息

Gouda M A, Hu M I, Cabanillas M E, Wu J, Meric-Bernstam F, Subbiah V

机构信息

Departments of Investigational Cancer Therapeutics.

Departments of Endocrine Neoplasia and Hormonal Disorders, The University of Texas MD Anderson Cancer Center, Houston.

出版信息

Ann Oncol. 2023 Oct;34(10):946-948. doi: 10.1016/j.annonc.2023.07.002. Epub 2023 Jul 19.

Abstract
摘要

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Brief Report: Chylothorax and Chylous Ascites During RET Tyrosine Kinase Inhibitor Therapy.
J Thorac Oncol. 2022 Sep;17(9):1130-1136. doi: 10.1016/j.jtho.2022.06.008. Epub 2022 Jul 2.
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Precision therapy for RET-altered cancers with RET inhibitors.
Trends Cancer. 2021 Dec;7(12):1074-1088. doi: 10.1016/j.trecan.2021.07.003. Epub 2021 Aug 12.
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GDF15/GFRAL Pathway as a Metabolic Signature for Cachexia in Patients with Cancer.
J Cancer. 2021 Jan 1;12(4):1125-1132. doi: 10.7150/jca.50376. eCollection 2021.
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Antibody-mediated inhibition of GDF15-GFRAL activity reverses cancer cachexia in mice.
Nat Med. 2020 Aug;26(8):1264-1270. doi: 10.1038/s41591-020-0945-x. Epub 2020 Jul 13.
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Targeting both sides of the GDF15-GFRAL-RET receptor complex: A new approach to achieve body weight homeostasis.
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