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Are haematopoietic stem cell transplants stem cell transplants, is there a threshold dose of CD34-positive cells and how many are needed for rapid posttransplant granulocyte recovery?

作者信息

Chen Junren, Gale Robert Peter, Feng Yahui, Hu Yu, Qi Saibing, Liu Xueou, Zhu Huaiping, Gong Xiaowen, Zhang Wei, Liu Huilan, Sun Zimin

机构信息

State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China.

Tianjin Institutes of Health Science, Tianjin, China.

出版信息

Leukemia. 2023 Oct;37(10):1963-1968. doi: 10.1038/s41375-023-01973-2. Epub 2023 Jul 20.

DOI:10.1038/s41375-023-01973-2
PMID:37474589
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10539175/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f595/10539175/9c540c761d00/41375_2023_1973_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f595/10539175/9c540c761d00/41375_2023_1973_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f595/10539175/9c540c761d00/41375_2023_1973_Fig1_HTML.jpg

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1
Are haematopoietic stem cell transplants stem cell transplants, is there a threshold dose of CD34-positive cells and how many are needed for rapid posttransplant granulocyte recovery?造血干细胞移植属于干细胞移植吗？CD34阳性细胞是否存在一个阈值剂量，以及移植后粒细胞快速恢复需要多少该细胞？
Leukemia. 2023 Oct;37(10):1963-1968. doi: 10.1038/s41375-023-01973-2. Epub 2023 Jul 20.
2
Peripheral blood stem cell transplants for multiple myeloma: identification of favorable variables for rapid engraftment in 225 patients.多发性骨髓瘤的外周血干细胞移植：225例患者中快速植入的有利变量识别
Blood. 1995 Jan 15;85(2):588-96.
3
Autologous transplantation of blood stem cells mobilized with filgrastim alone in 93 patients with malignancies: the number of CD34+ cells reinfused is the only factor predicting both granulocyte and platelet recovery.单用非格司亭动员的自体造血干细胞移植治疗93例恶性肿瘤患者：回输的CD34+细胞数量是预测粒细胞和血小板恢复的唯一因素。
J Hematother. 1996 Dec;5(6):663-70. doi: 10.1089/scd.1.1996.5.663.
4
Beyond CD34+ cell dose: impact of method of peripheral blood hematopoietic stem cell mobilization (granulocyte-colony-stimulating factor [G-CSF], G-CSF plus plerixafor, or cyclophosphamide G-CSF/granulocyte-macrophage [GM]-CSF) on number of colony-forming unit-GM, engraftment, and Day +100 hematopoietic graft function.超越 CD34+ 细胞剂量：外周血造血干细胞动员方法（粒细胞集落刺激因子[G-CSF]、G-CSF 加plerixafor 或环磷酰胺 G-CSF/粒细胞-巨噬细胞[GM]-CSF）对集落形成单位-GM 数量、植入和第 100 天造血移植物功能的影响。
Transfusion. 2011 Sep;51(9):1995-2000. doi: 10.1111/j.1537-2995.2011.03085.x. Epub 2011 Mar 10.
5
Allogeneic blood stem cell transplantation: peripheralization and yield of donor-derived primitive hematopoietic progenitor cells (CD34+ Thy-1dim) and lymphoid subsets, and possible predictors of engraftment and graft-versus-host disease.异基因造血干细胞移植：供体来源的原始造血祖细胞（CD34+ Thy-1dim）和淋巴细胞亚群的外周血出现情况及产量，以及植入和移植物抗宿主病的可能预测因素。
Blood. 1995 Oct 1;86(7):2842-8.
6
Effect of CD34+ selection and various schedules of stem cell reinfusion and granulocyte colony-stimulating factor priming on hematopoietic recovery after high-dose chemotherapy for breast cancer.CD34+选择、干细胞回输的不同方案以及粒细胞集落刺激因子预激对乳腺癌大剂量化疗后造血恢复的影响。
Blood. 1997 Mar 1;89(5):1521-8.
7
Use of granulocyte colony-stimulating factor after high-dose chemotherapy and autologous peripheral blood stem cell transplantation: what is the optimal timing?大剂量化疗及自体外周血干细胞移植后粒细胞集落刺激因子的应用：最佳时机是什么？
Am J Clin Oncol. 2001 Feb;24(1):19-25. doi: 10.1097/00000421-200102000-00003.
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Preceding chemotherapy, tumour load and age influence engraftment in multiple myeloma patients mobilized with granulocyte colony-stimulating factor alone.在化疗之前，肿瘤负荷和年龄会影响仅使用粒细胞集落刺激因子动员的多发性骨髓瘤患者的植入情况。
Br J Haematol. 2001 Jan;112(1):242-7. doi: 10.1046/j.1365-2141.2001.02498.x.
9
Correction: Are haematopoietic stem cell transplants stem cell transplants, is there a threshold dose of CD34-positive cells and how many are needed for rapid posttransplant granulocyte recovery?纠正：造血干细胞移植是否属于干细胞移植，CD34 阳性细胞是否存在阈值剂量，以及移植后粒细胞快速恢复需要多少 CD34 阳性细胞？
Leukemia. 2023 Oct;37(10):2144-2145. doi: 10.1038/s41375-023-02012-w.
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Plerixafor plus granulocyte colony-stimulating factor versus placebo plus granulocyte colony-stimulating factor for mobilization of CD34(+) hematopoietic stem cells in patients with multiple myeloma and low peripheral blood CD34(+) cell count: results of a subset analysis of a randomized trial.培洛昔福联合粒细胞集落刺激因子与安慰剂联合粒细胞集落刺激因子动员多发性骨髓瘤且外周血 CD34+细胞计数低的患者中的 CD34+造血干细胞：一项随机试验的亚组分析结果。
Biol Blood Marrow Transplant. 2012 Oct;18(10):1564-72. doi: 10.1016/j.bbmt.2012.05.017. Epub 2012 Jun 6.

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Blood Lymphat Cancer. 2025 Aug 1;15:103-113. doi: 10.2147/BLCTT.S527790. eCollection 2025.
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Restoring mitochondrial function promotes hematopoietic reconstitution from cord blood following cryopreservation-related functional decline.恢复线粒体功能可促进冷冻保存相关功能衰退后脐带血的造血重建。
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本文引用的文献

1
The universal stem cell.全能干细胞。
Leukemia. 2022 Dec;36(12):2784-2792. doi: 10.1038/s41375-022-01715-w. Epub 2022 Oct 28.
2
Differentiation Epitopes Define Hematopoietic Stem Cells and Change with Cell Cycle Passage.分化抗原定义造血干细胞，并随细胞周期传递而改变。
Stem Cell Rev Rep. 2022 Oct;18(7):2351-2364. doi: 10.1007/s12015-022-10374-4. Epub 2022 May 3.
3
A latent subset of human hematopoietic stem cells resists regenerative stress to preserve stemness.人类造血干细胞的一个潜伏亚群能够抵抗再生应激，从而维持干细胞特性。
新药时代多发性骨髓瘤药物治疗对自体干细胞移植的影响
Front Oncol. 2025 Feb 14;15:1479164. doi: 10.3389/fonc.2025.1479164. eCollection 2025.
4
New criteria for estimating numbers of CD34-positive cells in a graft needed for posttransplant bone marrow recovery.用于估计移植后骨髓恢复所需移植物中CD34阳性细胞数量的新标准。
Leukemia. 2024 Dec;38(12):2735-2738. doi: 10.1038/s41375-024-02424-2. Epub 2024 Sep 25.
5
Ex vivo culture resting time impacts transplantation outcomes of genome-edited human hematopoietic stem and progenitor cells in xenograft mouse models.体外培养休眠时间影响基因编辑人类造血干祖细胞移植在异种移植小鼠模型中的移植结果。
Cytotherapy. 2024 Jun;26(6):641-648. doi: 10.1016/j.jcyt.2024.02.011. Epub 2024 Feb 24.
6
Have we been qualifying measurable residual disease correctly?我们对可测量残留病的判定是否正确？
Leukemia. 2023 Nov;37(11):2168-2172. doi: 10.1038/s41375-023-02026-4. Epub 2023 Sep 13.
Nat Immunol. 2021 Jun;22(6):723-734. doi: 10.1038/s41590-021-00925-1. Epub 2021 May 6.
4
Selection of unrelated donors and cord blood units for hematopoietic cell transplantation: guidelines from the NMDP/CIBMTR.无关供者和脐带血造血细胞移植的选择：来自 NMDP/CIBMTR 的指南。
Blood. 2019 Sep 19;134(12):924-934. doi: 10.1182/blood.2019001212. Epub 2019 Jul 10.
5
CD34 cell content of 126 341 cord blood units in the US inventory: implications for transplantation and banking.美国库存中 126341 个脐带血单位的 CD34 细胞含量：对移植和储存的影响。
Blood Adv. 2019 Apr 23;3(8):1267-1271. doi: 10.1182/bloodadvances.2018029157.
6
In Vivo Tracking of Human Hematopoiesis Reveals Patterns of Clonal Dynamics during Early and Steady-State Reconstitution Phases.体内人类造血追踪揭示早期和稳态重建阶段的克隆动力学模式。
Cell Stem Cell. 2016 Jul 7;19(1):107-19. doi: 10.1016/j.stem.2016.04.016. Epub 2016 May 26.
7
Infused total nucleated cell dose is a better predictor of transplant outcomes than CD34+ cell number in reduced-intensity mobilized peripheral blood allogeneic hematopoietic cell transplantation.在减低预处理强度的动员外周血异基因造血细胞移植中，输注的总有核细胞剂量比CD34+细胞数量更能预测移植结果。
Haematologica. 2016 Apr;101(4):499-505. doi: 10.3324/haematol.2015.134841. Epub 2016 Jan 14.
8
Concise reviews: A stem cell apostasy: a tale of four H words.简要综述：干细胞叛离：四个以H开头单词的故事
Stem Cells. 2015 Jan;33(1):15-20. doi: 10.1002/stem.1829.
9
Clonal analysis unveils self-renewing lineage-restricted progenitors generated directly from hematopoietic stem cells.克隆分析揭示了直接从造血干细胞产生的自我更新、谱系受限的祖细胞。
Cell. 2013 Aug 29;154(5):1112-1126. doi: 10.1016/j.cell.2013.08.007.
10
Lentiviral hematopoietic stem cell gene therapy in patients with Wiskott-Aldrich syndrome.慢病毒造血干细胞基因治疗 Wiskott-Aldrich 综合征患者。
Science. 2013 Aug 23;341(6148):1233151. doi: 10.1126/science.1233151. Epub 2013 Jul 11.