Department of Orthopedics and Traumatology, Erzurum Training and Research Hospital, Erzurum, Turkey.
Department of Obstetrics and Gynecology, Faculty of Medicine, Atatürk University, Erzurum, Turkey.
Turk J Med Sci. 2023 Jun;53(3):659-665. doi: 10.55730/1300-0144.5628. Epub 2023 Jun 19.
IGF-1 (insulin-like growth factor-1) is an important regulator of bone formation. Its deficiency has been associated with fetal growth disorders and hip dysplasia. The aim of this study was to evaluate whether IGF-1, IGF-BP3 (insulin like growth factorbinding protein 3), and IGF-BP5 levels in the umbilical cord blood can be predictive for early diagnosis of DDH.
Umbilical cord blood samples were collected from 860 mothers with pregnancies at high risk for DDH between October 2020 and January 2021. Mothers at 37-42 weeks of gestation, with risk factors for DDH, who delivered healthy infants were included. Blood samples were collected during delivery. Each eligible infant was medically followed up and underwent a hip ultrasound in the postnatal 2nd or 3rd month. Infants diagnosed with DDH were matched with a healthy cohort in terms of sex, birth weight, maternal age, and gestational week, and the IGF-1, IGF-BP3 and IGF-BP5 levels were studied and compared.
Evaluation was made of 20 infants diagnosed with DDH and 60 healthy infants. Of the total 80 infants, 72.5% were female.The umbilical cord blood levels of IGF-1 and IGF-BP3 were similar in both groups. The IGF-BP5 values were significantly lower in the DDH patient group. Except for DDH diagnosis, the other categorical variables of the study did not appear to influence the levels of any of the IGFs.
Umbilical blood samples could potentially help diagnose DDH. The levels of IGF-BP5 were shown to be significantly lower in infants with DDH.
IGF-1（胰岛素样生长因子-1）是骨形成的重要调节剂。其缺乏与胎儿生长障碍和髋关节发育不良有关。本研究旨在评估脐带血中 IGF-1、IGF-BP3（胰岛素样生长因子结合蛋白 3）和 IGF-BP5 水平是否可预测 DDH 的早期诊断。
2020 年 10 月至 2021 年 1 月期间，收集了 860 名患有 DDH 高危妊娠的母亲的脐带血样本。纳入了 37-42 周妊娠、有 DDH 危险因素且分娩健康婴儿的母亲。在分娩期间采集血液样本。对每个符合条件的婴儿进行医学随访，并在产后第 2 或第 3 个月进行髋关节超声检查。将患有 DDH 的婴儿与性别、出生体重、母亲年龄和妊娠周数相匹配的健康队列进行比较，并研究和比较了 IGF-1、IGF-BP3 和 IGF-BP5 水平。
评估了 20 名患有 DDH 的婴儿和 60 名健康婴儿。在总共 80 名婴儿中，72.5%为女性。两组的脐带血 IGF-1 和 IGF-BP3 水平相似。IGF-BP5 值在 DDH 患者组中明显较低。除了 DDH 诊断外，研究的其他分类变量似乎并没有影响任何 IGF 的水平。
脐带血样本可能有助于诊断 DDH。患有 DDH 的婴儿 IGF-BP5 水平明显较低。
