Gorący Anna, Rosik Jakub, Szostak Joanna, Szostak Bartosz, Retfiński Szymon, Machaj Filip, Pawlik Andrzej
Department of Clinical and Molecular Biochemistry, Pomeranian Medical University, Szczecin, Poland.
Department of Physiology, Pomeranian Medical University, Szczecin, Poland.
Expert Opin Ther Targets. 2023 Jul-Dec;27(7):593-608. doi: 10.1080/14728222.2023.2240021. Epub 2023 Jul 24.
Heart failure is a complex clinical syndrome resulting from the unsuccessful compensation of symptoms of myocardial damage. Mitochondrial dysfunction is a process that occurs because of an attempt to adapt to the disruption of metabolic and energetic pathways occurring in the myocardium. This, in turn, leads to further dysfunction in cardiomyocyte processes. Currently, many therapeutic strategies have been implemented to improve mitochondrial function, but their effectiveness varies widely.
This review focuses on new models of therapeutic strategies targeting mitochondrial function in the treatment of heart failure.
Therapeutic strategies targeting mitochondria appear to be a valuable option for treating heart failure. Currently, the greatest challenge is to develop new research models that could restore the disrupted metabolic processes in mitochondria as comprehensively as possible. Only the development of therapies that focus on improving as many dysregulated mitochondrial processes as possible in patients with heart failure will be able to bring the expected clinical improvement, along with inhibition of disease progression. Combined strategies involving the reduction of the effects of oxidative stress and mitochondrial dysfunction, appear to be a promising possibility for developing new therapies for a complex and multifactorial disease such as heart failure.
心力衰竭是一种复杂的临床综合征，由心肌损伤症状的代偿失败所致。线粒体功能障碍是由于试图适应心肌中发生的代谢和能量途径紊乱而出现的过程。这反过来又导致心肌细胞过程进一步功能障碍。目前，已实施了许多治疗策略来改善线粒体功能，但其有效性差异很大。
本综述重点关注针对心力衰竭治疗中线粒体功能的治疗策略新模型。
针对线粒体的治疗策略似乎是治疗心力衰竭的一个有价值的选择。目前，最大的挑战是开发新的研究模型，尽可能全面地恢复线粒体中被破坏的代谢过程。只有开发出专注于改善心力衰竭患者尽可能多的失调线粒体过程的疗法，才能够带来预期的临床改善，并抑制疾病进展。涉及降低氧化应激和线粒体功能障碍影响的联合策略，似乎是为心力衰竭这种复杂的多因素疾病开发新疗法的一个有前景的可能性。
