Department of Otorhinolaryngology-Head and Neck Surgery, China Medical University Hospital, Taichung, Taiwan.
Department of Otorhinolaryngology-Head and Neck Surgery, Asia University Hospital, Taichung, Taiwan.
Laryngoscope. 2024 Mar;134(3):1071-1076. doi: 10.1002/lary.30905. Epub 2023 Jul 21.
Chronic rhinosinusitis (CRS) reduces the health-related quality of life and subsequently causes a tremendous socio-economic impact. Although many studies have been conducted, few have identified a relationship between bacteriological characteristics and different phenotypes or endotypes. Therefore, this study aimed to elucidate the recent trends in bacterial cultures from different types of CRS in the Asian population.
This retrospective case-control study recruited patients diagnosed with CRS who underwent functional endoscopic sinus surgery (FESS) at a tertiary hospital in Taiwan. The patients were classified into those with chronic rhinosinusitis with nasal polyps (CRSwNP)/chronic rhinosinusitis without nasal polyps (CRSsNP), eosinophilic chronic rhinosinusitis (eCRS)/non-eosinophilic chronic rhinosinusitis (NECRS), and central compartment atopic disease (CCAD)/lateral-dominant nasal polyp (LDNP) groups. The demographic data and bacteriological characteristics of the groups were analyzed.
We included 503 patients, identifying no significant difference between CRSwNP and CRSsNP for several common bacteria in CRS. The number of Staphylococcus epidermidis isolates in culture was significantly higher in the NECRS group (50.46% vs. 32.56%, p = 0.0003) than that in the eCRS group. The number of methicillin-resistant Staphylococcus aureus (MRSA; 8.51% vs. 2.35%, p = 0.0221) positive isolates was significantly higher in the CCAD group than that in the LDNP group.
This was the first study in Asia to analyze the relationship between bacteriological characteristics and CCAD. MRSA is significantly higher in the CCAD group than that in the LDNP group. Recognizing the unique microbiology of CRSwNP, eCRS, and CCAD is crucial when selecting antimicrobial therapy to lessen the socio-economic impact.
3 Laryngoscope, 134:1071-1076, 2024.
慢性鼻-鼻窦炎（CRS）降低了生活质量，并由此带来了巨大的社会经济影响。尽管已经进行了许多研究，但很少有研究能确定细菌学特征与不同表型或内型之间的关系。因此，本研究旨在阐明亚洲人群中不同类型 CRS 的细菌培养的最新趋势。
本回顾性病例对照研究招募了在台湾一家三级医院接受功能性内镜鼻窦手术（FESS）的 CRS 患者。患者分为慢性鼻-鼻窦炎伴鼻息肉（CRSwNP）/慢性鼻-鼻窦炎不伴鼻息肉（CRSsNP）、嗜酸性慢性鼻-鼻窦炎（eCRS）/非嗜酸性慢性鼻-鼻窦炎（NECRS）、中央隔腔变应性疾病（CCAD）/外侧优势型鼻息肉（LDNP）组。分析了各组的人口统计学数据和细菌学特征。
我们纳入了 503 例患者，CRSwNP 和 CRSsNP 两组中几种常见 CRS 细菌无显著差异。NECRS 组的表皮葡萄球菌培养分离株数量明显高于 eCRS 组（50.46%比 32.56%，p=0.0003）。耐甲氧西林金黄色葡萄球菌（MRSA）阳性分离株数量在 CCAD 组（8.51%）明显高于 LDNP 组（2.35%，p=0.0221）。
这是亚洲首例分析细菌学特征与 CCAD 之间关系的研究。MRSA 在 CCAD 组中的比例明显高于 LDNP 组。认识到 CRSwNP、eCRS 和 CCAD 的独特微生物学特征对于选择抗菌治疗以减轻社会经济影响至关重要。
3 级喉镜，134：1071-1076，2024。
