Department of Pediatrics, Dortcelik Children's Hospital, Bursa, Turkey.
Department of Neonatology, Dortcelik Children's Hospital, Bursa, Turkey.
Fetal Pediatr Pathol. 2023 Aug;42(4):589-598. doi: 10.1080/15513815.2023.2178866. Epub 2023 Feb 22.
We investigated the relationship between 25-hydroxyvitamin D (25-OHD) levels and the development of hemodynamically significant patent ductus arteriosus (hsPDA) in preterm infants.
Newborns having a gestational age (GA) of ≤32 weeks with hsPDA consisted the study group ( = 25, 20%), while newborns ≤32 weeks of GA without PDA/hsPDA were the control group ( = 97, 80%).
The study group had lower GA, birth weight (BW) and 25-OHD levels ( < 0.0001, = 0.002 and = 0.003, respectively). After adjusting for the effects of GA, BW and the presence of respiratory distress syndrome, multivariable logistic regression analyses demonstrated that preterm infants with low 25-OHD levels were 6.407 (95% CI: 1.656-24.788, = 0.007) times more likely to experience hsPDA than preterm infants with normal 25-OHD levels. Every 1 ng/mL increase in 25-OHD levels decreased the probability of hsPDA (OR: 0.894, 95% CI: 0.816-0.98, = 0.016). Low 25-OHD levels may have a role in the development of hsPDA.
我们研究了 25-羟维生素 D（25-OHD）水平与早产儿发生血流动力学意义未闭动脉导管（hsPDA）的关系。
本研究纳入胎龄（GA）≤32 周伴 hsPDA 的新生儿为研究组（ = 25，20%），同期纳入胎龄（GA）≤32 周无 PDA/hsPDA 的新生儿为对照组（ = 97，80%）。
研究组的 GA、出生体重（BW）和 25-OHD 水平更低（ < 0.0001， = 0.002 和 = 0.003）。多变量逻辑回归分析显示，在校正 GA、BW 和呼吸窘迫综合征的影响后，25-OHD 水平低的早产儿发生 hsPDA 的可能性是 25-OHD 水平正常早产儿的 6.407 倍（95%CI：1.656-24.788， = 0.007）。25-OHD 水平每增加 1ng/mL，hsPDA 的可能性就降低（OR：0.894，95%CI：0.816-0.98， = 0.016）。低 25-OHD 水平可能与 hsPDA 的发生有关。
