Liu Qian, Zhu Wen-Bing
Research Institute of Reproductive and Stem Cell Engineering, School of Basic Medicine, Central South University, Changsha, Hunan 420078, China.
Zhongxin Xiangya Hospital of Reproduction and Genetics, Changsha, Hunan 420078, China.
Zhonghua Nan Ke Xue. 2022 Jun;28(6):538-543.
Recent studies have confirmed that, in addition to sperm DNA, environmental exposure factors such as parental diet structure and stress state affect early embryonic development and offspring growth, thus leading to cross-generational inheritance of acquired traits. Many studies also show that environmental stressors can change the expression level of sperm small non-coding RNAs (sncRNAs). Furthermore, as the carrier of paternal genetic information transmission and epigenetic marker, sncRNAs are directly or indirectly involved in epigenetic regulation, mediating inter-generational inheritance of acquired traits. This review focuses on the two sncRNAs derived from microRNA (miRNA) and tRNA (tsRNA) in sperm epigenetics research.
最近的研究证实，除精子DNA外，诸如父母饮食结构和应激状态等环境暴露因素会影响早期胚胎发育和子代生长，从而导致获得性性状的跨代遗传。许多研究还表明，环境应激源可改变精子小非编码RNA（sncRNAs）的表达水平。此外，作为父系遗传信息传递和表观遗传标记的载体，sncRNAs直接或间接参与表观遗传调控，介导获得性性状的代际遗传。本综述聚焦于精子表观遗传学研究中源自微小RNA（miRNA）和转运RNA（tsRNA）的两类sncRNAs。
