Xu Ping, Wang Min, Zhang Tingting, Zhang Junjun, Jin Zhenlan, Li Ling
MOE Key Laboratory for Neuroinformation, High-Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province, Center for Psychiatry and Psychology, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, 610054, China.
Bioinformatics and BioMedical Bigdata Mining Laboratory, School of Big Health, Guizhou Medical University, Guiyang, China.
Brain Struct Funct. 2024 Dec;229(9):2493-2508. doi: 10.1007/s00429-023-02687-y. Epub 2023 Jul 21.
Maintained working memory (WM) representations have been shown to influence visual target detection selection, while the effect of the visual target detection process on WM retrieval remains largely unknown. In the current research, we used the dual-paradigm of the visual target detection task and the delayed matching task (DMT), which contained the following four conditions: the match condition: the DMT target contained the detection target; the mismatch condition: the DMT target contained the detection distractor; the neutral condition: only the detection target was presented; the catch condition: only the DMT target was presented. Twenty-six subjects were recruited in the experiment with simultaneous EEG-fMRI data. Behaviorally, faster responses were found in the mismatch condition than in the match and neutral conditions. The EEG data found a greater parieto-occipital N1 component in the mismatch condition compared to the neutral condition, and a greater frontal N2 component in the match condition than in the mismatch condition. Moreover, compared to the match and neutral conditions, weaker activations of the bilateral middle frontal gyrus (MFG) were observed in the mismatch condition. And the representational similarity analysis (RSA) revealed significant differences in the representational patterns of the bilateral MFG between mismatch and match conditions, as well as in the representational patterns of the left MFG between mismatch and neutral conditions. Additionally, the left MFG may be the brain source of the N1 component in the mismatch condition. These findings suggest that the mismatch between the DMT target and detection target affects early attention allocation and attentional control in WM retrieval, and the MFG may play an important role in WM retrieval by the effect of the target detection task. In conclusion, our work deepens the understanding of the neural mechanisms by which visual target detection affects WM retrieval.
已有研究表明，维持性工作记忆（WM）表征会影响视觉目标检测选择，而视觉目标检测过程对WM检索的影响在很大程度上仍不清楚。在当前研究中，我们使用了视觉目标检测任务和延迟匹配任务（DMT）的双范式，其中包含以下四种条件：匹配条件：DMT目标包含检测目标；不匹配条件：DMT目标包含检测干扰项；中性条件：仅呈现检测目标；捕捉条件：仅呈现DMT目标。实验招募了26名受试者，同时采集脑电图-功能磁共振成像（EEG-fMRI）数据。行为学上，发现不匹配条件下的反应比匹配和中性条件下更快。脑电图数据发现，与中性条件相比，不匹配条件下顶枕叶N1成分更大，与不匹配条件相比，匹配条件下额叶N2成分更大。此外，与匹配和中性条件相比，不匹配条件下双侧额中回（MFG）的激活较弱。表征相似性分析（RSA）显示，不匹配和匹配条件下双侧MFG的表征模式存在显著差异，不匹配和中性条件下左侧MFG的表征模式也存在显著差异。此外，左侧MFG可能是不匹配条件下N1成分的脑源。这些发现表明，DMT目标与检测目标之间的不匹配会影响WM检索中的早期注意力分配和注意力控制，并且MFG可能通过目标检测任务的作用在WM检索中发挥重要作用。总之，我们的工作加深了对视觉目标检测影响WM检索的神经机制的理解。
Zotero 插件