COVID-19 住院儿童和青少年的营养风险与临床结局：一项多中心队列研究。
Nutritional risk and clinical outcomes of COVID-19 in hospitalized children and adolescents: a multicenter cohort.
机构信息
Universidade Federal da Bahia (UFBA), Escola de Nutrição, Nutrição Clínica, Salvador, BA, Brazil.
Universidade Federal do Rio Grande do Norte (UFRN), Faculdade de Ciências da Saúde do Trairi, Saúde Coletiva, Natal, RN, Brazil.
出版信息
J Pediatr (Rio J). 2023 Nov-Dec;99(6):641-647. doi: 10.1016/j.jped.2023.06.001. Epub 2023 Jul 18.
OBJECTIVE
To verify the association between nutritional risk on admission and clinical outcomes of COVID-19 in hospitalized children and adolescents.
METHODS
Multicenter cohort study was conducted in two cities in the northeastern region of Brazil, with children under 18 years of age laboratory diagnosed with COVID-19. Sociodemographic data and nutritional risk screening by STRONGKids (low, medium and high risk) were collected remotely and in hospital records, respectively. The outcomes assessed were the need for ICU admission, length of stay (< 10 days or ≥ 10 days), critical cases, and death. Multivariable logistic regression models were used to evaluate the effects of high nutritional risk on COVID-19 clinical outcomes.
RESULTS
103 individuals were evaluated, of these 35 (34.0%) had low risk, 44 (42.7%) medium risk, and 24 (23.3%) had high risk of malnutrition. In multivariate analysis, ICU bed admission (OR: 4.57; 95%CI, 1.39-4.97; p = 0.01), hospitalization longer than or equal to ten days (OR: 3.96; 95%CI, 1.22-2.83; p = 0.02) and critical cases (OR: 4.35; 95%CI, 1.08-7.55; p = 0.04) were associated with high nutritional risk. Death was not associated with high nutritional risk.
CONCLUSIONS
Children and adolescents with high nutritional risk by STRONGkids at hospital admission were more likely to be admitted to the ICU, have hospitalization longer than or equal to ten days, and have critical cases when infected with SARS-CoV-2.
目的
验证入院时的营养风险与住院儿童和青少年 COVID-19 临床结局的关系。
方法
本多中心队列研究在巴西东北部的两个城市进行，纳入年龄在 18 岁以下、经实验室诊断为 COVID-19 的儿童。通过 STRONGkids（低、中、高风险）分别远程和住院记录收集社会人口统计学数据和营养风险筛查。评估的结局包括入住 ICU、住院时间（< 10 天或≥ 10 天）、危重症病例和死亡。采用多变量逻辑回归模型评估高营养风险对 COVID-19 临床结局的影响。
结果
共评估了 103 名患者，其中 35 名（34.0%）风险低，44 名（42.7%）风险中，24 名（23.3%）风险高。多变量分析显示，入住 ICU（OR：4.57；95%CI，1.39-4.97；p=0.01）、住院时间≥10 天（OR：3.96；95%CI，1.22-2.83；p=0.02）和危重症病例（OR：4.35；95%CI，1.08-7.55；p=0.04）与高营养风险相关。死亡与高营养风险无关。
结论
入院时通过 STRONGkids 评估为高营养风险的儿童和青少年在感染 SARS-CoV-2 时更有可能入住 ICU、住院时间≥10 天和发生危重症病例。
Zotero 插件