Caimi P, Eisenstark A
Mutat Res. 1986 Sep;162(2):145-51. doi: 10.1016/0027-5107(86)90080-1.
Although Dienococcus radiodurans is notoriously resistant to far-ultraviolet radiation (FUV; 254 nm), it is highly sensitive to near-ultraviolet radiation (NUV; 300-400 nm), thus demonstrating that the mechanisms of damage (and/or recovery) by the two types of irradiation are different. This observed difference between FUV and NUV effects in D. radiodurans agrees with previous studies with Escherichia coli. Near-ultraviolet radiation produces DNA damage which is presumed to be single-strand breaks (SSB) in the DNA of D. radiodurans. Unique lesions, such as DNA-protein crosslinks could not be demonstrated in this study. Cells that were pre-irradiated with a small dose of NUV were subsequently protected against inactivating doses of NUV. The data presented are consistent with induced DNA repair following NUV damage in D. radiodurans; this is in contrast to FUV damage where DNA repair is constitutive but not induced.
尽管耐辐射球菌对远紫外线辐射（FUV；254纳米）具有众所周知的抗性，但它对近紫外线辐射（NUV；300 - 400纳米）高度敏感，这表明两种类型辐射的损伤（和/或恢复）机制不同。在耐辐射球菌中观察到的FUV和NUV效应之间的这种差异与先前对大肠杆菌的研究一致。近紫外线辐射会产生DNA损伤，据推测这是耐辐射球菌DNA中的单链断裂（SSB）。在本研究中未能证实存在诸如DNA - 蛋白质交联等独特损伤。预先用小剂量NUV照射的细胞随后受到保护，免受致死剂量NUV的影响。所呈现的数据与耐辐射球菌中NUV损伤后诱导的DNA修复一致；这与FUV损伤形成对比，FUV损伤时DNA修复是组成型的而非诱导型的。
