The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, Wuhan University, China; Department of Oral and Maxillofacial Trauma and Temporomandibular Joint Surgery, Hubei-MOST KLOS & KLOBM, School & Hospital of Stomatology, Wuhan University, China.
The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, Wuhan University, China; Department of Oral and Maxillofacial Trauma and Temporomandibular Joint Surgery, Hubei-MOST KLOS & KLOBM, School & Hospital of Stomatology, Wuhan University, China.
Arch Oral Biol. 2023 Oct;154:105765. doi: 10.1016/j.archoralbio.2023.105765. Epub 2023 Jul 11.
This review aims to systematically summarize the methods of establishing various models of trigeminal neuralgia (TN), the scope of application, and current animals used in TN research and the corresponding pain measurements, hoping to provide valuable reference for researchers to select appropriate TN animal models and make contributions to the research of pathophysiology and management of the disease.
The related literatures of TN were searched through PubMed database using different combinations of the following terms and keywords including but not limited: animal models, trigeminal neuralgia, orofacial neuropathic pain. To find the maximum number of eligible articles, no filters were used in the search. The references of eligible studies were analyzed and reviewed comprehensively.
This study summarized the current animal models of TN, categorized them into the following groups: chemical induction, photochemical induction, surgery and genetic engineering, and introduced various measurement methods to evaluate animal pain behaviors.
Although a variety of methods are used to establish disease models, there is no ideal TN model that can reflect all the characteristics of the disease. Therefore, there is still a need to develop more novel animal models in order to further study the etiology, pathological mechanism and potential treatment of TN.
本综述旨在系统总结各种三叉神经痛（TN）模型的建立方法、适用范围以及目前用于 TN 研究的动物及相应的疼痛测量方法，以期为研究人员选择合适的 TN 动物模型提供有价值的参考，为疾病的病理生理学和管理研究做出贡献。
通过 PubMed 数据库，使用以下术语和关键词的不同组合搜索 TN 的相关文献，包括但不限于：动物模型、三叉神经痛、口腔面神经病痛。为了找到最多数量的合格文章，搜索中未使用任何过滤器。对合格研究的参考文献进行了全面的分析和综述。
本研究总结了目前的 TN 动物模型，将其分为以下几类：化学诱导、光化学诱导、手术和基因工程，并介绍了各种评估动物疼痛行为的测量方法。
尽管有多种方法用于建立疾病模型，但仍没有能够反映疾病所有特征的理想 TN 模型。因此，仍需要开发更多新的动物模型，以便进一步研究 TN 的病因、病理机制和潜在治疗方法。
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