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不同表面热源下考虑温度相关热导率和代谢的烧伤损伤的数值模拟。

Numerical simulation of burn injuries with temperature-dependent thermal conductivity and metabolism under different surface heat sources.

机构信息

Department of Mathematics, Institute of Science, Banaras Hindu University, Varanasi, 221005, India.

出版信息

J Therm Biol. 2023 Aug;116:103656. doi: 10.1016/j.jtherbio.2023.103656. Epub 2023 Jul 16.

Abstract

In the present paper, the phenomena of heat transport inside human forearm tissue are studied through a one-dimensional nonlinear bioheat transfer model under the influence of various boundary and interface conditions. In this study, we considered temperature-dependent thermal conductivity and metabolic heat to predict temperature distribution inside the forearm tissue. We have studied the temperature distribution inside inner tissue and bone because it has been found that burn injuries are mostly affected by layer thickness. The temperature distribution inside human forearm tissue is analyzed using the finite difference and bvp4c numerical techniques. To examine the accuracy of present numerical code, we compare the obtained numerical result with the exact analytical result in a specific case and find an excellent agreement with the exact results. We also validated our present numerical code with a hybrid scheme based on Runge-Kutta (4,5) and finite difference technique and found it in good compliance. From the obtained results, we observed that the homogeneous heat flux has a greater impact on the temperature at the outer surface of the skin, but the sinusoidal heat flux has a greater impact on the temperature of the subcutaneous layer and inner tissue. It is found that there is no burn injury in the first type of heat source (T=44°C), but it may occur in the second and third types of heat sources. It has been observed that by raising the blood perfusion rate and reducing the values of reference metabolic heat, coefficient of thermal conductivity, and heat fluxes, we can manage and reduce burn injuries and achieve hyperthermia temperature.

摘要

在本文中,通过考虑温度相关的热导率和代谢热,我们研究了在各种边界和界面条件影响下,人体前臂组织内的一维非线性生物传热现象。我们预测了前臂组织内的温度分布,研究了内层组织和骨骼内的温度分布,因为已经发现烧伤损伤主要受层厚度的影响。我们使用有限差分和 bvp4c 数值技术分析了人体前臂组织内的温度分布。为了检验当前数值代码的准确性,我们在特定情况下将获得的数值结果与精确解析结果进行了比较,发现与精确结果非常吻合。我们还使用基于龙格-库塔(4,5)和有限差分技术的混合方案验证了我们当前的数值代码,发现其符合良好。从得到的结果中,我们观察到,均匀热通量对皮肤外表面的温度有更大的影响,而正弦热通量对皮下层和内层组织的温度有更大的影响。结果表明,在第一种热源(T=44°C)下没有烧伤损伤,但在第二种和第三种热源下可能会发生。已经观察到,通过提高血液灌注率,降低参考代谢热、热导率和热通量的值,可以控制和减少烧伤损伤,并达到高热温度。

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