Department of Mechanical Engineering, National Institute of Technology Silchar, Assam, 788010, India.
Department of Mechanical Engineering, National Institute of Technology Silchar, Assam, 788010, India.
J Therm Biol. 2022 Dec;110:103368. doi: 10.1016/j.jtherbio.2022.103368. Epub 2022 Oct 11.
Cancer treatment is achieved by destroying the damaged tissue with precise heating, which may be internally or externally on a human body. Thus, tracking the temperature at the targeted site during thermal therapy is essential to avoid unnecessary damage to the neighbouring tissues. Therefore, to avoid difficulties in the experimental in-vivo analysis of the human body, more and more priority has been given to computational modelling. Dual-phase lag bioheat transfer modelling is one that pioneers the biological heat transfer problem to a new horizon where the non-Fourier approach makes the model near realistic. The present paper has developed a numerical model based on the Local Thermal Non-Equilibrium Bioheat Transfer model, as the phase lag values directly depend on the biological tissues' thermophysical properties. Besides the effect of vasodilation and vasoconstriction, metabolic heat generation, as well as muscle shivering, are also considered in the present numerical model. A modified spatial Gaussian heat distribution function has been adapted to model the external heat source and destroy the targeted tissue inside the skin layers. A numerical code is developed using MATLAB in a finite difference approach, which can evaluate the temperature data in an anisotropic medium like human skin. A detailed 2D analysis has been done in different therapeutic conditions, various levels of doses, and different body positions during interstitial hyperthermia treatment. Analysis of biological tissue using the LTNE DPL bioheat transfer equation has not been reported for thermal therapy. Outcomes of the present study give an overview of the range of thermal dose, environmental effect on the treatment of cancer cells, and, most notably, the comparison with Fourier and Local Thermal Equilibrium Non-Fourier models.
癌症治疗是通过精确加热来破坏受损组织实现的，这种加热既可以在人体内部进行，也可以在外部进行。因此，在热疗过程中跟踪目标部位的温度对于避免对周围组织造成不必要的损伤至关重要。因此，为了避免人体实验分析中的困难，越来越多的研究开始关注计算建模。双相滞后生物传热建模是将生物传热问题推向新的前沿的先驱，其中非傅里叶方法使模型更接近实际情况。本文基于局部热非平衡生物传热模型开发了一个数值模型，因为相位滞后值直接取决于生物组织的热物理性质。除了血管舒张和血管收缩的影响外，本数值模型还考虑了代谢产热和肌肉颤抖的影响。本文采用了改进的空间高斯热分布函数来模拟外部热源，以破坏皮肤层内的目标组织。采用有限差分方法在 MATLAB 中开发了一个数值代码，可以评估像人体皮肤这样的各向异性介质中的温度数据。在间质热疗治疗过程中，针对不同的治疗条件、不同剂量水平和不同的体位进行了详细的 2D 分析。在热疗中，使用 LTNE DPL 生物传热方程对生物组织进行分析尚未有报道。本研究的结果概述了热剂量范围、环境对癌细胞治疗的影响，特别是与傅里叶和局部热平衡非傅里叶模型的比较。
