School of Public Health, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, China.
Department of Anesthesiology, Sanbo Brain Hospital, Capital Medical University, Beijing, China.
Cerebrovasc Dis. 2024;53(3):261-269. doi: 10.1159/000531861. Epub 2023 Jul 21.
Several observational studies have indicated that polyunsaturated fatty acid serum levels (PUFAs) are associated with vascular dementia (VaD), but their causal relationships remain elusive. Therefore, we attempted to evaluate the causal effect of PUFAs on VaD in a two-sample Mendelian randomization (MR) analysis by using summary statistics from aggregated genome-wide association studies.
The inverse-variance weighted (IVW) method was performed as the primary analysis. Sensitivity analyses (MR-Egger regression, weighted median, penalized weighted median, and MR pleiotropy residual sum and outlier methods) were also implemented to estimate the effects of potential violations of MR hypotheses.
No causality was found for PUFAs (odds ratio, 1.14; 95% confidence interval, 0.91-1.42; p = 0.25) on VaD in the IVW model. The results were consistent in sensitivity analyses. There was no notable horizontal pleiotropy or heterogeneity.
In this two-sample MR analysis, our findings did not support the assumption that PUFAs play causal role in the occurrence or development of VaD.
几项观察性研究表明，多不饱和脂肪酸（PUFAs）的血清水平与血管性痴呆（VaD）有关，但它们之间的因果关系仍难以捉摸。因此，我们尝试通过使用汇总的全基因组关联研究的汇总统计数据，在两样本 Mendelian 随机化（MR）分析中评估 PUFAs 对 VaD 的因果效应。
采用逆方差加权（IVW）方法作为主要分析方法。还进行了敏感性分析（MR-Egger 回归、加权中位数、惩罚加权中位数和 MR 偏倚残差和异常值方法），以估计对潜在违反 MR 假设的影响。
在 IVW 模型中，PUFAs（比值比，1.14；95%置信区间，0.91-1.42；p = 0.25）与 VaD 之间没有因果关系。敏感性分析的结果一致。没有明显的水平偏倚或异质性。
在这项两样本 MR 分析中，我们的发现不支持 PUFAs 在 VaD 的发生或发展中起因果作用的假设。
