光学相干断层扫描在保乳手术切缘评估中的诊断准确性：系统评价和荟萃分析。
Diagnostic accuracy of optical coherence tomography for margin assessment in breast-conserving surgery: A systematic review and meta-analysis.
机构信息
Department of Epidemiology and Statistics, School of Public Health, Jilin University, Changchun, Jilin, China.
School of Mathematics and Statistics, Northeast Normal University, Changchun, Jilin, China.
出版信息
Photodiagnosis Photodyn Ther. 2023 Sep;43:103718. doi: 10.1016/j.pdpdt.2023.103718. Epub 2023 Jul 21.
BACKGROUND
Breast cancer is the most common malignant tumor among women, and its incidence is increasing annually. At present, the results of the study on whether optical coherence tomography (OCT) can be used as an intraoperative margin assessment method for breast-conserving surgery (BCS) are inconsistent. We herein conducted this systematic review and meta-analysis to assess the diagnostic value of OCT in BCS.
METHODS
PubMed, Web of Science, Cochrane Library, and Embase were used to search relevant studies published up to September 15, 2022. We used Review Manager 5.4, Meta-Disc 1.4, and STATA 16.0 for statistical analysis.
RESULTS
The results displayed 18 studies with 782 patients included according to the inclusion and exclusion criteria. Meta-analysis showed the pooled sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (DOR) and the area under the curve (AUC) of OCT in the margin assessment of BCS were 0.91 (95% CI 0.88-0.93), 0.88 (95% CI 0.83-0.92), 7.53 (95% CI 5.19-10.93), 0.11(95% CI 0.08-0.14), 70.37 (95% CI 39.78-124.47), and 0.94 (95% CI 0.92-0.96), respectively.
CONCLUSIONS
OCT is a promising technique in intraoperative margin assessment of breast cancer patients.
背景
乳腺癌是女性最常见的恶性肿瘤，其发病率呈逐年上升趋势。目前，关于光相干断层扫描（OCT）是否可作为保乳手术（BCS）术中切缘评估方法的研究结果并不一致。本系统评价和荟萃分析旨在评估 OCT 在 BCS 中的诊断价值。
方法
检索 PubMed、Web of Science、Cochrane Library 和 Embase 数据库，截至 2022 年 9 月 15 日，收集有关 OCT 用于 BCS 术中切缘评估的研究。采用 Review Manager 5.4、Meta-Disc 1.4 和 STATA 16.0 进行统计分析。
结果
根据纳入和排除标准，共纳入 18 项研究，包含 782 例患者。Meta 分析结果显示，OCT 评估 BCS 切缘的合并敏感度、特异度、阳性似然比（PLR）、阴性似然比（NLR）、诊断比值比（DOR）和曲线下面积（AUC）分别为 0.91（95%CI 0.88-0.93）、0.88（95%CI 0.83-0.92）、7.53（95%CI 5.19-10.93）、0.11（95%CI 0.08-0.14）、70.37（95%CI 39.78-124.47）和 0.94（95%CI 0.92-0.96）。
结论
OCT 是一种有前途的乳腺癌患者术中切缘评估技术。
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