Pediatrics department, College of Medicine and Health Sciences, Arba Minch University, Arba Minch, Ethiopia.
Pediatrics department, College of Medicine and Health Sciences, Hawassa University, Hawassa, Ethiopia.
Ethiop J Health Sci. 2023 Mar;33(2):327-336. doi: 10.4314/ejhs.v33i2.18.
Epilepsy accounts for 0.5 % of the world's disease burden. Around 80 % of these are living in low and middle-income countries. In Ethiopia, the prevalence is 0.6 to 5 per 1000 population. There is a little study in our study area on the treatment and predictors of response of adult epilepsy. The purpose of this study was to determine the treatment outcome and its associated factors among adult epileptic patients in public hospitals in southern Ethiopia.
Multi-centered, Hospital-based cross-sectional study was conducted from October 2021 - august 2022. Data were collected by face-to-face interviews and record review. Data was analysed using SPSS. The bivariate and multivariable logistic regression analyses have been performed between the dependent and the independent variables.
Of the total 422 participants, 55.9 % were males and 62.6% were below 30 years of age. The most common type of seizure was a generalized tonic-clonic seizure. Most (87.9 %) were treated by immunotherapy. Phenobarbitone is most common medication (77.5). One-quarter reported adverse effects of medication. The majority (78%) had good control (seizure free for at least one year) and 22% had poor control. Poor medication adherence (AOR=4.03) and shorter duration of seizure before treatment (AOR=4.233) were associated with poor control.
A significant number of patients had poor control of seizures. Early identification of issues on medication adherence and early initiation of treatment will improve treatment outcome.
癫痫占全球疾病负担的 0.5%。其中约 80%的患者生活在中低收入国家。在埃塞俄比亚，癫痫的患病率为每 1000 人口 0.6 至 5 人。在我们的研究地区，针对成人癫痫的治疗和反应预测因素的研究很少。本研究旨在确定埃塞俄比亚南部公立医院成年癫痫患者的治疗结果及其相关因素。
这项多中心、基于医院的横断面研究于 2021 年 10 月至 2022 年 8 月进行。通过面对面访谈和病历回顾收集数据。使用 SPSS 进行数据分析。在依赖变量和独立变量之间进行了双变量和多变量逻辑回归分析。
在总共 422 名参与者中，55.9%是男性，62.6%年龄在 30 岁以下。最常见的癫痫发作类型是全面强直阵挛发作。大多数（87.9%）接受免疫治疗。苯巴比妥是最常见的药物（77.5%）。四分之一的人报告了药物的不良反应。大多数（78%）控制良好（至少一年无癫痫发作），22%控制不佳。药物依从性差（AOR=4.03）和治疗前癫痫发作持续时间较短（AOR=4.233）与控制不佳相关。
相当多的患者癫痫发作控制不佳。早期发现药物依从性问题并尽早开始治疗将改善治疗结果。
