心力衰竭中的心房颤动：在尼日利亚奥格博莫索的缺铁和心力衰竭中的贫血（IDAN-HF）研究中的流行病学、生活质量和临床特征。

Atrial Fibrillation in Heart Failure: Epidemiology, Quality of Life and Clinical Characteristics in the Iron Deficiency and ANaemia in Heart Failure (IDAN-HF) Study in Ogbomoso, Nigeria.

机构信息

Department of Medicine, LAUTECH Teaching Hospital, Ogbomoso, Nigeria.

Goshen Heart Clinic, Osogbo, Osun State, Nigeria.

出版信息

Ethiop J Health Sci. 2023 Mar;33(2):245-254. doi: 10.4314/ejhs.v33i2.9.

DOI:10.4314/ejhs.v33i2.9

PMID:37484170

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10358381/

Abstract

BACKGROUND

The cluster of atrial fibrillation (AF) with heart failure (HF) may be associated with a poorer prognosis. Its epidemiology and impact on clinical outcomes and quality of life among HF subjects in Africa have not yet been fully described. This study aimed at describing the epidemiology of AF among HF subjects, its impact on quality of life, clinical characteristics, and associations.

METHODS

140 HF subjects were recruited by stratified random sampling method, and 12-lead electrocardiography was done to diagnose AF. Statistical analysis was done with SPSS 21.0. Informed consent was obtained from all participants.

RESULTS

The frequency occurrence of AF was 28 (20.0%) of the HF subjects and were similar in age, systolic blood pressure, diastolic blood pressure, right ventricular internal dimension, packed cell volume, and gender distribution with those in sinus rhythm. The mean (S.D) six minutes walk test distance was significantly lower among HF subjects with AF compared to those without AF (171.1± 88.9 vs. 225.8 ± 102.1m respectively, p <0.05). Pulmonary hypertension, intracardiac clots, and kidney dysfunction were more frequent among HF subjects with AF than among those without AF. HF subjects with AF had a higher frequency of clusters of comorbidities than those without AF. AF was most prevalent and left atrial dimension was highest among subjects who had HF with reduced ejection fraction, compared to other HF phenotypes.

CONCLUSION

AF is common in HF among Nigerians and is associated with poor quality of life and poorer functional status compared to those with sinus rhythm.

摘要

背景

心房颤动（AF）伴心力衰竭（HF）的发生率较高，其预后可能较差。非洲 HF 患者中 AF 的流行病学特征及其对临床结局和生活质量的影响尚未完全阐明。本研究旨在描述 HF 患者中 AF 的流行病学特征、对生活质量的影响、临床特征及相关因素。

方法

采用分层随机抽样法招募 140 例 HF 患者，行 12 导联心电图检查以诊断 AF。采用 SPSS 21.0 进行统计学分析。所有参与者均获得知情同意。

结果

HF 患者中 AF 的发生率为 28 例（20.0%），其年龄、收缩压、舒张压、右心室内径、红细胞压积和性别分布与窦性心律患者相似。与无 AF 的 HF 患者相比，AF 的 HF 患者的六分钟步行试验距离明显更短（分别为 171.1±88.9m 和 225.8±102.1m，p<0.05）。AF 的 HF 患者中肺动脉高压、心腔内血栓和肾功能不全的发生率高于无 AF 的 HF 患者。与无 AF 的 HF 患者相比，AF 的 HF 患者的合并症发生率更高。与其他 HF 表型相比，射血分数降低的 HF 患者中 AF 最常见，左心房内径最高。