Rose Lucy, Owusu-Brackett Nicci, Moore Stephen, Oppong Bridget
Division of Surgical Oncology, Department of Surgery The Ohio State University Wexner Medical Center Columbus Ohio USA.
Department of Pathology The Ohio State University Wexner Medical Center Columbus Ohio USA.
Clin Case Rep. 2023 Jul 19;11(7):e7539. doi: 10.1002/ccr3.7539. eCollection 2023 Jul.
Post-radiation angiosarcoma of the breast is a rare complication associated with a poor prognosis. This case reports the first loss of function mutation in TSC1 in breast radiation-induced angiosarcoma and illustrates the utility of evaluating these markers to identify potential therapeutic targets.
Post-radiation angiosarcoma of the breast is rare and associated with a poor prognosis. This case presents the first loss of function mutation in TSC1 in breast radiation-induced angiosarcoma. Evaluation of these markers can aid in identifying potential therapeutic targets.
乳腺放疗后血管肉瘤是一种罕见的并发症，预后较差。本病例报告了乳腺放疗诱导的血管肉瘤中TSC1的首个功能丧失突变，并说明了评估这些标志物以确定潜在治疗靶点的实用性。
乳腺放疗后血管肉瘤罕见，预后较差。本病例呈现了乳腺放疗诱导的血管肉瘤中TSC1的首个功能丧失突变。评估这些标志物有助于确定潜在的治疗靶点。
