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丰富环境诱导的缺血性脑卒中神经可塑性及其潜在机制。

Enriched environment-induced neuroplasticity in ischemic stroke and its underlying mechanisms.

作者信息

Han Ping-Ping, Han Yu, Shen Xin-Ya, Gao Zhen-Kun, Bi Xia

机构信息

Department of Rehabilitation Medicine, Shanghai University of Medicine and Health Sciences Affiliated Zhoupu Hospital, Shanghai, China.

Department of Sport Rehabilitation, Shanghai University of Sport, Shanghai, China.

出版信息

Front Cell Neurosci. 2023 Jul 7;17:1210361. doi: 10.3389/fncel.2023.1210361. eCollection 2023.

Abstract

is a common cerebrovascular disease that can interrupt local blood flow in the brain, causing neuronal damage or even death, resulting in varying degrees of neurological dysfunction. is an important neurological function that helps neurons reorganize and regain function after injury. After cerebral ischemia, neuroplasticity changes are critical factors for restoring brain function. An enriched environment promotes increased neuroplasticity, thereby aiding stroke recovery. In this review, we discuss the positive effects of the enriched environment on neuroplasticity after cerebral ischemia, including synaptic plasticity, neurogenesis, and angiogenesis. In addition, we also introduce some studies on the clinical application of enriched environments in the rehabilitation of post-stroke patients, hoping that they can provide some inspiration for doctors and therapists looking for new approaches to stroke rehabilitation.

摘要

是一种常见的脑血管疾病,可中断大脑局部血流,导致神经元损伤甚至死亡,从而引发不同程度的神经功能障碍。是一项重要的神经功能,有助于神经元在损伤后重新组织并恢复功能。脑缺血后,神经可塑性变化是恢复脑功能的关键因素。丰富的环境可促进神经可塑性增强,从而有助于中风恢复。在本综述中,我们讨论了丰富的环境对脑缺血后神经可塑性的积极影响,包括突触可塑性、神经发生和血管生成。此外,我们还介绍了一些关于丰富环境在中风后患者康复中的临床应用的研究,希望它们能为寻求中风康复新方法的医生和治疗师提供一些启发。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5147/10360187/7c21eb23b0ec/fncel-17-1210361-g001.jpg

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