Girona Neuroimmunology and Multiple Sclerosis Unit, Neurology Department, Dr. Josep Trueta University Hospital and Santa Caterina Hospital, Salt, Spain.
Neurodegeneration and Neuroinflammation Research Group, Girona Biomedical Research Institute (IDIBGI), Salt, Spain.
Eur J Neurol. 2023 Oct;30(10):3357-3361. doi: 10.1111/ene.15988. Epub 2023 Jul 31.
Progressive multifocal leukoencephalopathy is a rare but often fatal complication of some multiple sclerosis treatments. Although it has mainly been associated with natalizumab treatment, its appearance with other immunosuppressive therapies has also been reported.
The aim of this case report is to describe the development of progressive multifocal encephalopathy in a patient with relapsing-remitting multiple sclerosis treated with ocrelizumab without previous use of natalizumab.
A summary of the presentation and disease course is provided, presented in the context of the current literature and likely pathophysiology.
进行性多灶性白质脑病是一些多发性硬化症治疗的罕见但通常致命的并发症。尽管它主要与那他珠单抗治疗有关，但也有报告称在使用其他免疫抑制剂治疗时出现这种情况。
本病例报告的目的是描述一名接受奥瑞珠单抗治疗的复发性多发性硬化症患者发生进行性多灶性脑白质病的发展情况，该患者以前未使用过那他珠单抗。
本文总结了患者的临床表现和疾病过程，并结合当前文献和可能的发病机制进行了讨论。
