Parker C R, Hankins G D, Carr B R, Gant N F, MacDonald P C, Porter J C
Pediatr Res. 1986 Sep;20(9):876-8. doi: 10.1203/00006450-198609000-00014.
The effect of hypertension in pregnant women on fetal maturation is an issue of considerable importance. Because of a possible role of prolactin in fetal adrenal steroidogenesis and in fetal lung maturation, we have investigated the relationship between hypertension in pregnant women and levels of prolactin and dehydroepiandrosterone sulfate in serum of newborn infants. It was found that with the mild-to-moderate form of pregnancy-induced hypertension (PIH), there was little effect on prolactin levels in newborn serum. In newborns of women with severe PIH, however, serum prolactin levels were significantly greater (p less than 0.01) than those in newborns of women with uncomplicated pregnancies. Conversely, umbilical serum concentrations of dehydroepiandrosterone sulfate in newborns of women with severe PIH were significantly less (p less than 0.05) than those in newborns of women with uncomplicated pregnancies. These findings are supportive of the view that pituitary function and adrenocortical function of fetuses of women with PIH are different from those of fetuses of normotensive women. These findings are suggestive that PIH alters the function of the fetal pituitary and adrenal cortex.
孕妇高血压对胎儿成熟的影响是一个相当重要的问题。由于催乳素可能在胎儿肾上腺类固醇生成及胎儿肺成熟过程中发挥作用，我们研究了孕妇高血压与新生儿血清中催乳素及硫酸脱氢表雄酮水平之间的关系。结果发现，轻度至中度妊娠高血压综合征（PIH）对新生儿血清催乳素水平影响不大。然而，患有重度PIH的孕妇所生新生儿的血清催乳素水平显著高于（p<0.01）无并发症妊娠孕妇所生新生儿。相反，患有重度PIH的孕妇所生新生儿脐带血清中硫酸脱氢表雄酮浓度显著低于（p<0.05）无并发症妊娠孕妇所生新生儿。这些发现支持以下观点，即患有PIH的孕妇胎儿的垂体功能和肾上腺皮质功能与血压正常孕妇的胎儿不同。这些发现提示PIH会改变胎儿垂体和肾上腺皮质的功能。
