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父亲的关怀独特地影响男性神经发育。

Father's care uniquely influences male neurodevelopment.

机构信息

Department of Psychology, University of Virginia, Charlottesville, VA 22904.

Program in Fundamental Neuroscience, University of Virginia, Charlottesville, VA 22904.

出版信息

Proc Natl Acad Sci U S A. 2023 Aug;120(31):e2308798120. doi: 10.1073/pnas.2308798120. Epub 2023 Jul 24.

DOI:10.1073/pnas.2308798120
PMID:37487074
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10400995/
Abstract

Mammalian infants depend on parental care for survival, with numerous consequences for their behavioral development. We investigated the epigenetic and neurodevelopmental mechanisms mediating the impact of early biparental care on development of alloparenting behavior, or caring for offspring that are not one's own. We find that receiving high parental care early in life leads to slower epigenetic aging of both sexes and widespread male-specific differential expression of genes related to synaptic transmission and autism in the nucleus accumbens. Examination of parental care composition indicates that high-care fathers promote a male-specific increase in excitatory synapses and increases in pup retrieval behavior as juveniles. Interestingly, females raised by high-care fathers have the opposite behavioral response and display fewer pup retrievals. These results support the concept that neurodevelopmental trajectories are programmed by different features of early-life parental care and reveal that male neurodevelopmental processes are uniquely sensitive to care by fathers.

摘要

哺乳动物幼崽依赖父母的照顾才能生存，这对它们的行为发育有诸多影响。我们研究了介导早期双亲照料对代际照料行为（即照料非亲生后代）发展影响的表观遗传和神经发育机制。我们发现，生命早期获得高父母照顾会导致两性的表观遗传衰老速度减缓，并且在伏隔核中与突触传递和自闭症相关的基因出现广泛的雄性特异性差异表达。对父母照顾组成的研究表明，高照顾父亲会促进雄性幼崽兴奋性突触的特异性增加，并在青少年时期增加幼崽的回收行为。有趣的是，由高照顾父亲抚养的雌性表现出相反的行为反应，并且回收幼崽的次数较少。这些结果支持了这样一种概念，即神经发育轨迹是由早期生活中父母照顾的不同特征所编程的，并揭示了雄性神经发育过程对父亲的照顾特别敏感。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a47d/10400995/80777d3267fb/pnas.2308798120fig05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a47d/10400995/6e3f7e69823a/pnas.2308798120fig01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a47d/10400995/824cb3626aaa/pnas.2308798120fig02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a47d/10400995/35bb5ac243dd/pnas.2308798120fig03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a47d/10400995/9cbf0a22bf70/pnas.2308798120fig04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a47d/10400995/80777d3267fb/pnas.2308798120fig05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a47d/10400995/6e3f7e69823a/pnas.2308798120fig01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a47d/10400995/824cb3626aaa/pnas.2308798120fig02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a47d/10400995/35bb5ac243dd/pnas.2308798120fig03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a47d/10400995/9cbf0a22bf70/pnas.2308798120fig04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a47d/10400995/80777d3267fb/pnas.2308798120fig05.jpg

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