National Clinical Research Center of kidney Diseases, JinLing Hospital, Nanjing University School of medicine, Nanjing, China.
Lupus. 2023 Aug;32(9):1066-1074. doi: 10.1177/09612033231187229. Epub 2023 Jul 24.
The study delves into the clinical efficacy and safety of centrifugal-membranous hybrid double filtration plasmapheresis (C/M hybrid DFPP) on severe lupus nephritis (LN) by comparing it with membranous DFPP (M DFPP).
A retrospective cohort study was conducted in 70 patients who were diagnosed with severe LN and had received DFPP treatment.
A total of 181 DFPPs were performed, including 133 C/M hybrid DFPPs (51 patients) and 48 M DFPPs (19 patients).The ANA, A-dsDNA titer, quantitative urinary protein, and serum creatinine decreased significantly and hemoglobin increased significantly after the DFPP treatment and at third month after treatment. Two patients in the M DFPP group developed bleeding complications, and four patients in the C/M hybrid DFPP group developed perioral numbness.
Although there was no significant difference in clinical efficacy between C/M hybrid DFPP and M DFPP on severe LN, the risk of bleeding complications was significantly lower in the C/M hybrid DFPP group.
通过对比膜式双重滤过血浆置换（MDFPP）与离心膜式混合双重滤过血浆置换（C/M 混合 DFPP），研究严重狼疮肾炎（LN）的临床疗效和安全性。
对 70 例接受 DFPP 治疗的严重 LN 患者进行回顾性队列研究。
共进行了 181 次 DFPP，包括 51 例患者的 133 次 C/M 混合 DFPP 和 19 例患者的 48 次 MDFPP。DFPP 治疗后及治疗后 3 个月，ANA、A-dsDNA 滴度、定量尿蛋白和血清肌酐明显下降，血红蛋白明显升高。MDFPP 组 2 例患者发生出血并发症，C/M 混合 DFPP 组 4 例患者发生口唇麻木。
虽然 C/M 混合 DFPP 与 MDFPP 治疗严重 LN 的临床疗效无显著差异，但 C/M 混合 DFPP 组出血并发症风险显著降低。
