Integrative Sciences and Engineering Programme, NUS Graduate School, National University of Singapore, Singapore.
Healthy Longevity Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
J Am Med Dir Assoc. 2023 Nov;24(11):1655-1662.e3. doi: 10.1016/j.jamda.2023.06.015. Epub 2023 Jul 21.
Our study evaluated the prospective association between the consumption of caffeine-containing beverages at midlife and the risk of physical frailty at late life within a population-based cohort of Chinese adults living in Singapore over a follow-up period of 20 years.
Prospective cohort study.
We used data from 12,583 participants from the baseline and third follow-up interviews of the Singapore Chinese Health Study (SCHS). Participants had a mean age of 53 years at baseline (1993-1998), and a mean age of 73 years during the third follow-up (2014-2017).
At baseline, habitual consumption of caffeine-containing beverages was evaluated using a validated semi-quantitative food-frequency questionnaire. During the third follow-up, physical frailty was assessed using the modified Cardiovascular Health Study phenotype.
Compared with non-daily drinkers, those who drank 4 or more cups of coffee daily had reduced odds of physical frailty [odds ratio (OR), 0.54; 95% CI, 0.38-0.76]. Similarly, compared with those who hardly drank tea, participants who drank tea everyday also had reduced odds (OR, 0.82; 95% CI, 0.71-0.95). Total daily caffeine intake at midlife was associated with reduced likelihood of frailty at late life in a dose-response relationship (P < .001). Relative to their counterparts in the lowest quartile of daily caffeine intake (0-67.6 mg/d), participants in the highest quartile (223.0-910.4 mg/d) had an OR of 0.77 (95% CI, 0.66-0.91). Higher caffeine consumption was associated with lower likelihood of being in the slowest quintile for timed up-and-go (TUG) and weakest quintile for handgrip strength.
In this cohort of Chinese adults, higher consumption of caffeine at midlife, via coffee and tea, was associated with a reduced likelihood of physical frailty in late life.
本研究在新加坡的一项基于人群的中国成年人队列中，评估了中年时期摄入含咖啡因饮料与 20 年随访期间晚年身体虚弱风险之间的前瞻性关联。
前瞻性队列研究。
我们使用了新加坡华人健康研究（SCHS）基线和第三次随访访谈中 12583 名参与者的数据。参与者的基线平均年龄为 53 岁（1993-1998 年），第三次随访时的平均年龄为 73 岁（2014-2017 年）。
在基线时，使用经过验证的半定量食物频率问卷评估习惯性摄入含咖啡因饮料。在第三次随访期间，使用改良的心血管健康研究表型评估身体虚弱。
与非每日饮用者相比，每日饮用 4 杯或更多杯咖啡的人身体虚弱的几率降低[比值比（OR），0.54；95%置信区间（CI），0.38-0.76]。同样，与几乎不喝茶的人相比，每天喝茶的人身体虚弱的几率也降低（OR，0.82；95%CI，0.71-0.95）。中年时期的每日总咖啡因摄入量与晚年虚弱的可能性呈剂量反应关系（P<0.001）。与每日咖啡因摄入量最低四分位数（0-67.6mg/d）的参与者相比，摄入量最高四分位数（223.0-910.4mg/d）的参与者身体虚弱的 OR 为 0.77（95%CI，0.66-0.91）。较高的咖啡因摄入量与 TUG 最慢五分位和握力最弱五分位的可能性较低有关。
在这项中国成年人队列中，中年时期通过咖啡和茶摄入更多的咖啡因与晚年身体虚弱的可能性降低有关。
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