Rietveld I B, Barrio M, Ceolin R, Tamarit J Ll
SMS Laboratory (UR 3233, Université Rouen-Normandie, Place Émile Blondel, 76821, Mont Saint Aignan, France.
Faculté de Pharmacie, Université Paris Cité, 4 Avenue de l'observatoire, 75006, Paris, France.
Sci Rep. 2023 Jul 24;13(1):11914. doi: 10.1038/s41598-023-38985-y.
For over a century, it was thought that the crystalline polymorph II of benzophenone does not possess a stable domain in the pressure-temperature phase diagram. With a combination of new experimental results and literature data, this case of crystalline dimorphism has finally been solved and it is shown that form II possesses a stable domain at high pressure and high temperature, even though its density is lower than that of form I, the stable form under ordinary pressure and temperature conditions. The phase diagram of benzophenone is a clear demonstration of the fact that to understand the phase behaviour of a chemical substance both the exchange of heat (due to the change in intermolecular interactions) and work (due to the change of volume at a given pressure) need to be taken into account.
一个多世纪以来，人们一直认为二苯甲酮的晶型多晶型物II在压力-温度相图中不存在稳定区域。结合新的实验结果和文献数据，这一晶体多晶型现象终于得到解决，结果表明，尽管晶型II的密度低于在常压和常温条件下的稳定晶型I，但它在高压和高温下具有稳定区域。二苯甲酮的相图清楚地表明，要理解一种化学物质的相行为，需要同时考虑热交换（由于分子间相互作用的变化）和功（由于在给定压力下体积的变化）。
