Disassociating drug active ingredients from inactive: ketamine-like synaptic effects of a ketamine excipient.
作者信息
Brown Kyle A, Gould Todd D
机构信息
Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, 21201, USA.
Department of Pharmacology, University of Maryland School of Medicine, Baltimore, MD, 21201, USA.
出版信息
Neuropsychopharmacology. 2024 Jan;49(1):301-302. doi: 10.1038/s41386-023-01675-4.
Abstract
摘要
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Disassociating drug active ingredients from inactive: ketamine-like synaptic effects of a ketamine excipient.将药物活性成分与非活性成分分离：一种氯胺酮辅料的类氯胺酮突触效应
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本文引用的文献
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Ketamine preservative benzethonium chloride potentiates hippocampal synaptic transmission and binds neurotransmitter receptors and transporters.氯苯甲铵作为氯胺酮防腐剂可增强海马突触传递，并与神经递质受体和转运体结合。
Neuropharmacology. 2023 Mar 1;225:109403. doi: 10.1016/j.neuropharm.2022.109403. Epub 2022 Dec 21.
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Excipient of paclitaxel induces metabolic dysregulation and unfolded protein response.紫杉醇辅料会诱导代谢失调和未折叠蛋白反应。
iScience. 2021 Sep 25;24(10):103170. doi: 10.1016/j.isci.2021.103170. eCollection 2021 Oct 22.
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The activities of drug inactive ingredients on biological targets.药物非活性成分对生物靶点的作用。
Science. 2020 Jul 24;369(6502):403-413. doi: 10.1126/science.aaz9906.
4
Synergistic inhibition of muscarinic signaling by ketamine stereoisomers and the preservative benzethonium chloride.氯胺酮立体异构体与防腐剂苄索氯铵对毒蕈碱信号传导的协同抑制作用。
Anesthesiology. 1997 Jun;86(6):1326-33. doi: 10.1097/00000542-199706000-00014.
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