Oddó D, González S
Pathol Res Pract. 1986 Jun;181(3):320-6. doi: 10.1016/S0344-0338(86)80110-8.
Actinomycosis and nocardiosis are bacterial infectious diseases with distinct morphologic features, that can be diagnosed in tissue sections. The clinico-pathologic features of 17 cases are reported with emphasis on their histopathologic diagnosis by using a simple combination of common tissue stains. Actinomycosis was frequently observed as a secondary and localized infection often with lung involvement, especially in residual cavities or bronchiectasis; in these cases numerous actinomycotic granules and only occasionally individual bacterial filaments within the suppurative foci and/or granulomas with suppurative centers were identified. Nocardiosis was observed as an opportunistic infection in the three cases studied; in these, isolated filaments of acid-fast and Gram-positive bacteria were observed. The morphologic features and the differential diagnosis in tissue sections of both infections are discussed with emphasis on their identification by the general pathologist in the routine material.
放线菌病和诺卡菌病是具有独特形态学特征的细菌性传染病，可在组织切片中诊断。本文报告了17例病例的临床病理特征，重点介绍了通过使用常见组织染色的简单组合进行组织病理学诊断的情况。放线菌病常表现为继发性局部感染，常累及肺部，尤其是在残余空洞或支气管扩张中；在这些病例中，在化脓性病灶和/或有化脓中心的肉芽肿内可发现大量放线菌颗粒，仅偶尔可见单个细菌丝。在所研究的3例病例中，诺卡菌病表现为机会性感染；在这些病例中，观察到抗酸且革兰氏阳性的细菌的孤立丝。讨论了这两种感染在组织切片中的形态学特征和鉴别诊断，重点是普通病理学家在常规材料中对它们的识别。
