Department of Otorhinolaryngology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea.
Department of Otorhinolaryngology, Yonsei University College of Medicine, Seoul, South Korea.
Head Neck. 2023 Sep;45(9):2369-2376. doi: 10.1002/hed.27473. Epub 2023 Jul 24.
We analyzed the difference in treatment results according to safety margin range and studied the role of adjuvant therapy in patients with human papillomavirus-positive (HPV+) oropharyngeal squamous cell carcinoma (OPSCC).
A total of 279 patients with HPV+ OPSCC were included in this study.
Surgical margin and T classification were significant prognostic factors related to death. The difference in locoregional recurrence was analyzed by dividing the safety margin into groups of <1, 1-5, and >5 mm. There was no significant difference in local-regional recurrence for T1-T2 lesions between the three groups. Adjuvant therapy can significantly reduce disease recurrence in HPV+ OPSCC patients with risk factors.
In T1-T2 lesions without other risk factors, even with a safety margin ≥1 mm, adjuvant therapy can potentially be omitted. Adjuvant therapy can significantly reduce disease recurrence in HPV+ OPSCC patients with risk factors.
我们分析了根据安全边缘范围的治疗结果差异，并研究了辅助治疗在 HPV 阳性（HPV+）口咽鳞状细胞癌（OPSCC）患者中的作用。
本研究共纳入 279 例 HPV+ OPSCC 患者。
手术切缘和 T 分类是与死亡相关的显著预后因素。通过将安全边缘分为<1、1-5 和>5mm 组来分析局部区域复发的差异。在三组中，T1-T2 病变的局部区域复发无显著差异。对于有危险因素的 HPV+ OPSCC 患者，辅助治疗可显著降低疾病复发率。
在没有其他危险因素的 T1-T2 病变中，即使安全边缘≥1mm，也可能不需要辅助治疗。辅助治疗可显著降低 HPV+ OPSCC 患者的疾病复发率。
