Sim Felix W, Xiao Hong D, Bell R Bryan
Head and Neck Institute, Providence Cancer Center, Providence Portland Medical Center, 4805 Northeast Glisan Street, Suite 6N50, Portland, OR 97213, USA.
Head and Neck Pathologist, Department of Pathology, Providence Portland Medical Center, 4805 Northeast Glisan Street, Suite 6N50, Portland, OR 97213, USA.
Oral Maxillofac Surg Clin North Am. 2017 Aug;29(3):269-280. doi: 10.1016/j.coms.2017.03.004.
Because of the common shared risk factors of smoking and heavy alcohol consumption, literature involving oropharyngeal squamous cell carcinoma (OPSCC) is often combined with oral squamous cell carcinoma. Human papilloma virus is now confirmed to be a major risk factor of OPSCC with its distinct epidemiology and favorable treatment outcome. The impact of adjuvant chemoradiation in the setting of positive surgical margins remains unclear but is likely influenced by tumor biology. This article reviews the tumor biology of OPSCC and summarizes recent findings on outcomes following surgical treatment of OPSCC.
由于吸烟和大量饮酒这些常见的共同风险因素，涉及口咽鳞状细胞癌（OPSCC）的文献通常与口腔鳞状细胞癌合并在一起。人乳头瘤病毒现已被确认为口咽鳞状细胞癌的主要风险因素，其流行病学特征独特且治疗效果良好。辅助放化疗在手术切缘阳性情况下的影响仍不明确，但可能受肿瘤生物学特性的影响。本文综述了口咽鳞状细胞癌的肿瘤生物学特性，并总结了口咽鳞状细胞癌手术治疗后近期的疗效研究结果。
