Lon S. Schneider, MD, MS, is Della Martin Chair of Psychiatry and Neuroscience, and Professor of Psychiatry, Neurology, and Gerontology in Keck School of Medicine at the University of Southern California, Los Angeles, CA.
Psychopharmacol Bull. 2023 Jul 12;53(2):8-65.
Introduction The purpose of this guide is to provide convenient and useful information on about Alzheimer's disease and dementias of late life. The information includes selected facts, diagnostic criteria tables, descriptions of selected tests and screens, guidelines, clinical pharmacological data and references. This guide is divided into several sections: Background factsDiagnostic aids and criteria for dementia diagnosesMedications used for Alzheimer's disease and dementia Basic information on marketed treatments is provided although the treatment may not be FDA approved for this use. Approved cholinesterase inhibitors, memantine, and monoclonal antibodies are listed. No treatment is recommended or endorsed, however. This guide does not address the evidence base for the efficacy of the treatments listed. : Except for treatments above, discussions of medications for people with dementia nearly always involve off label use. For example, antidepressants and antipsychotics are indicated in the FDA-approved prescribing information for major depression and schizophrenia, and not for depressive symptoms or the delusions or hallucinations occurring within the context of dementia with two exceptions. In these instances, the doses listed are for reference only and should not be considered as recommendations or appropriate use. Physicians should consult the product package labeling for any drug mentioned.
简介 本指南旨在提供有关老年痴呆症和痴呆症的便捷有用信息。信息包括选定的事实、诊断标准表、选定测试和筛查的描述、指南、临床药理学数据和参考资料。本指南分为以下几部分： 背景事实 痴呆症诊断的辅助工具和标准 用于治疗阿尔茨海默病和痴呆症的药物 提供了市售治疗方法的基本信息，尽管这些治疗方法可能未获得 FDA 批准用于这种用途。列出了已批准的胆碱酯酶抑制剂、美金刚和单克隆抗体。但是，没有推荐或认可任何治疗方法。本指南不涉及所列出治疗方法的疗效证据基础。 除上述治疗方法外，讨论痴呆症患者的药物治疗几乎总是涉及超说明书使用。例如，抗抑郁药和抗精神病药在 FDA 批准的用于重度抑郁症和精神分裂症的处方信息中有明确规定，而不是用于痴呆症伴有的抑郁症状或在痴呆症背景下出现的妄想或幻觉，只有两种情况除外。在这些情况下，列出的剂量仅供参考，不应被视为推荐或适当使用。医生应查阅所提到的任何药物的产品包装标签。
