Rosenthal E
Postgrad Med J. 1986 Jul;62(729):677-8. doi: 10.1136/pgmj.62.729.677.
Azathioprine has been used as an immunosuppressant for over 20 years in cancer chemotherapy, organ transplantation and diseases with confirmed or suspected immune mechanisms. A hypersensitivity reaction manifesting as fever, rash, myalgia and a neutrophil leucocytosis occurring about 2 weeks after exposure is well documented and has been confirmed by challenge testing. Hypotensive reactions are less common but potentially fatal; a case is reported where repeat exposure resulted in profound circulatory collapse responding only to intervention with inotropic agents.
硫唑嘌呤作为一种免疫抑制剂已在癌症化疗、器官移植以及确诊或疑似有免疫机制的疾病中使用了20多年。接触后约2周出现的以发热、皮疹、肌痛和中性粒细胞增多为表现的超敏反应已有充分记载，并经激发试验证实。低血压反应较少见但可能致命；有一例报告称，再次接触导致严重循环衰竭，仅用强心剂干预才有效。
