心脏移植受者中播散性隐球菌感染并发心肌炎的不常见表现。
Unusual presentation of disseminated cryptococcal infection complicated by myocarditis in a heart transplant recipient.
机构信息
Ryan White Center for Pediatric Infectious Diseases & Global Health, Indiana University, Indianapolis, Indiana, USA.
Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana, USA.
出版信息
Pediatr Transplant. 2024 Feb;28(1):e14585. doi: 10.1111/petr.14585. Epub 2023 Jul 25.
BACKGROUND
Cryptococcus neoformans is the third most common cause of invasive fungal infection in solid organ transplant (SOT) recipients. While cryptococcal infection can involve any organ, cases of myocarditis are exceedingly rare.
METHODS
A retrospective chart review was completed for this case report.
RESULTS
We present the case of a 21-year-old heart transplant recipient who developed disseminated cryptococcal infection with biopsy-proven cryptococcal myocarditis.
CONCLUSIONS
Cryptococcal disease in SOT recipients poses diagnostic and therapeutic challenges. There are no current guidelines for the duration of cryptococcal myocarditis treatment. Repeat myocardial biopsy may play a role in guiding length of therapy.
背景
新型隐球菌是实体器官移植（SOT）受者中侵袭性真菌感染的第三大常见原因。虽然隐球菌感染可累及任何器官，但心肌炎病例极为罕见。
方法
对该病例报告进行了回顾性图表审查。
结果
我们报告了一例 21 岁心脏移植受者的病例，该患者发生了播散性隐球菌感染，并经活检证实为隐球菌性心肌炎。
结论
SOT 受者的隐球菌病带来了诊断和治疗方面的挑战。目前尚无针对隐球菌性心肌炎治疗时间的指南。重复心肌活检可能在指导治疗时间方面发挥作用。
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