Safarbalou Asal, Ebrahimi Fatemeh, Amiri Fereshteh Talebpour, Hosseinimehr Seyed Jalal
Department of Pharmacy, Ramsar Campous, Mazandaran University of Medical Sciences, Ramsar, Iran.
Department of Radiopharmacy, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran.
Curr Radiopharm. 2024;17(1):38-45. doi: 10.2174/1874471016666230725112319.
Patients undergoing radiotherapy are prone to radiation-induced gastrointestinal injury. Piperine is an alkaloid component in black pepper with a unique chemopreventive activity against oxidative stress-related damage in healthy tissues. The purpose of this study was to investigate the effects of piperine on intestinal damage.
In this study, mice were divided into eight groups: including the control, piperine (10, 25, and 50 mg/kg), radiation (6 Gy), and piperine+radiation (10, 25 and 50 mg/kg + 6 Gy) groups. The radioprotective effects of piperine were evaluated by biochemical (MDA, GSH, and PC) and histopathological assessments in colon tissues.
The 10 mg/kg dose of piperine significantly reduced the levels of oxidative stress biomarkers compared to the group that received only radiation. In addition, pre-treatment with 10 mg/kg piperine diminished the histopathological changes like vascular congestion in the submucosa, while the dose of 50 mg/kg led to the infiltration of inflammatory cells.
Based on this study, it is concluded that piperine, at low dose, with its antioxidant properties, could reduce the colon damage caused by radiation.
接受放射治疗的患者容易发生放射性胃肠道损伤。胡椒碱是黑胡椒中的一种生物碱成分，对健康组织中与氧化应激相关的损伤具有独特的化学预防活性。本研究的目的是探讨胡椒碱对肠道损伤的影响。
在本研究中，小鼠被分为八组：包括对照组、胡椒碱组（10、25和50mg/kg）、辐射组（6Gy）以及胡椒碱+辐射组（10、25和50mg/kg + 6Gy）。通过对结肠组织进行生化（丙二醛、谷胱甘肽和磷脂酰胆碱）和组织病理学评估来评价胡椒碱的辐射防护作用。
与仅接受辐射的组相比，10mg/kg剂量的胡椒碱显著降低了氧化应激生物标志物的水平。此外，用10mg/kg胡椒碱预处理可减轻组织病理学变化，如黏膜下层血管充血，而50mg/kg剂量则导致炎性细胞浸润。
基于本研究，得出结论：低剂量的胡椒碱凭借其抗氧化特性可减轻辐射引起的结肠损伤。
