Ataturk University School of Medicine, Department of Radiation Oncology, Erzurum, Turkey.
J BUON. 2021 Mar-Apr;26(2):626-633.
Despite the therapeutic effects of radiotherapy on tumor cells, it has potential severe adverse effects on the surrounding normal tissues. Acute or chronic intestinal adverse effects that are likely to occur in patients undergoing radiotherapy for pelvic and abdominal cancers lead to increased morbidity, significant impairment of the quality of life, and economic losses. Various biological, chemical and pharmacological agents are being tested to protect from and to treat radiation enteritis. This experimental study aimed to investigate the protective effects of melatonin against radiation-induced intestinal injury when administered before radiation exposure in rats.
In the present study, villus height and the number of villi in the ileum and jejunum of rats receiving two different doses of intraperitoneal melatonin (5 and 10 mg/kg) prior to a single fraction of radiation given at a dose of 8 Gy to the abdominal region, was evaluated by histopathological examination 3 and 7 days after radiation exposure.
At a dose of 5 mg/kg, melatonin was found to be effective in preventing radiation-induced injury to villus height in the jejunum and the number of villi in the ileum and jejunum, and at a dose of 10 mg/kg it was also effective in preventing radiation-induced injury to villus height in the ileum.
Melatonin is effective for the prevention of radiation-induced intestinal injury. This outcome can be considered an evidence to test melatonin in clinical trials.
尽管放疗对肿瘤细胞具有治疗作用，但它对周围正常组织也有潜在的严重不良反应。盆腔和腹部癌症患者在接受放疗后，可能会发生急性或慢性肠道不良反应，从而导致发病率增加、生活质量显著受损和经济损失。目前正在测试各种生物、化学和药理学制剂，以预防和治疗放射性肠炎。本实验研究旨在探讨给予放射前腹腔内给予褪黑素对大鼠肠道损伤的保护作用。
在本研究中，通过组织病理学检查评估了腹腔内给予两种不同剂量褪黑素（5 和 10 mg/kg）后，在腹部接受单次 8 Gy 剂量放射后 3 天和 7 天，大鼠回肠和空肠的绒毛高度和绒毛数量。
5 mg/kg 剂量的褪黑素可有效预防空肠绒毛高度和回肠及空肠绒毛数量的放射损伤，10 mg/kg 剂量的褪黑素也可有效预防回肠的绒毛高度的放射损伤。
褪黑素可有效预防放射性肠损伤。这一结果可以作为在临床试验中测试褪黑素的依据。
