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管理影响患有炎症性肠病的非裔美国女性的妊娠和哺乳:临床结果与为人父母情况

Managing Pregnancy and Nursing Affecting African American Women with Inflammatory Bowel Disease: Clinical Outcomes and Parenthood.

作者信息

M'Koma Amosy E, Ware Jamie N, Nabaweesi Rosemary K, Chirwa Sanika S

机构信息

Departments of Biochemistry, Cancer Biology, Neuroscience and Pharmacology.

Departments of Obstetrics and Gynecology.

出版信息

Med Res Arch. 2023 Jun;11(6). doi: 10.18103/mra.v11i6.3784. Epub 2023 Jun 26.

Abstract

Inflammatory bowel disease (IBD) is a term for two autoimmune diseases encompassing Crohn's disease (CD) and ulcerative colitis (UC) which are lifelong diseases affecting more than 3 million adults (1.3%) in the United States. IBD is characterized by chronic inflammation of the whole digestive system which results in damage to the gastrointestinal (GI) tract. IBD often emerges during adolescence and young adulthood. Maternal morbidity includes physical and psychological conditions that result from or are aggravated by pregnancy and have an adverse effect on a woman's health, the baby's health or both. Some women have health challenges that arise before or during pregnancy that could lead to complications. It is recommended for women to receive health care counseling before and during pregnancy. Compared to other developed countries, the United States has the highest rate of women dying of pregnancy related complications. During the past 25 years maternal mortality has been getting worse. African American women (AAW) with and/or without IBD are dying at significantly higher rates than other groups. This is linked to several factors, i.e., systemic, institutionalized, and structural racism in health-care delivery and subsequent toxic stress from people's lived experiences of racism, limited knowledge about healthcare system function, lack of access to healthcare, (inclusiveness and insurance policies) all of which negatively impact these patients. African Americans (AAs) are also up to three times as likely to experience severe maternal morbidity: unexpected outcomes of labor and delivery, deficient or lacking prenatal care and social determinants of health like lack of transportation, adequate employment, limited literacy, and limited healthcare access contribute to poor health outcomes. Studies on IBD patients indicate Medicaid expansion is associated with reduced rates of maternal morbidity, particularly for African American Women (AAW) and increased access to preconception and prenatal services that make pregnancy and childbirth safer for parent and baby. Herein we examine the physiological changes of pregnancy in patients diagnosed with inflammatory bowel disease and their relationship perinatal outcomes and parenthood.

摘要

炎症性肠病(IBD)是两种自身免疫性疾病的统称,包括克罗恩病(CD)和溃疡性结肠炎(UC),这是一种终身疾病,在美国影响着超过300万成年人(占1.3%)。IBD的特征是整个消化系统的慢性炎症,会导致胃肠道(GI)受损。IBD通常在青春期和青年期出现。孕产妇发病包括由怀孕引起或因怀孕而加重的身体和心理状况,并对女性健康、婴儿健康或两者都产生不利影响。一些女性在怀孕前或怀孕期间会出现可能导致并发症的健康问题。建议女性在怀孕前和怀孕期间接受医疗保健咨询。与其他发达国家相比,美国因妊娠相关并发症死亡的女性比例最高。在过去25年里,孕产妇死亡率一直在恶化。患有和/或未患有IBD的非裔美国女性(AAW)的死亡率明显高于其他群体。这与几个因素有关,即医疗保健服务中的系统性、制度化和结构性种族主义,以及人们因种族主义经历而产生的后续毒性应激、对医疗保健系统功能的了解有限、缺乏医疗保健服务(包括包容性和保险政策),所有这些都对这些患者产生负面影响。非裔美国人(AA)发生严重孕产妇发病的可能性也高达三倍:分娩意外结果、产前护理不足或缺乏,以及健康的社会决定因素,如交通不便、就业不足、识字率有限和医疗保健服务机会有限,都会导致不良健康结果。对IBD患者的研究表明,医疗补助扩大与孕产妇发病率降低有关,特别是对非裔美国女性(AAW)而言,并且增加了孕前和产前服务的可及性,从而使怀孕和分娩对母亲和婴儿更安全。在此,我们研究被诊断为炎症性肠病的患者在怀孕期间的生理变化及其与围产期结局和为人父母的关系。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5ad2/10367541/27e5779f7ac2/nihms-1914981-f0001.jpg

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