Jackson Tiaranesha K, Sow Yacine, Ayoade Katherine Omueti, Seykora John T, Taylor Susan C, Ogunleye Temitayo
University of Illinois College of Medicine, Peoria, Illinois.
Morehouse School of Medicine, Atlanta, Georgia.
J Am Acad Dermatol. 2023 Dec;89(6):1136-1140. doi: 10.1016/j.jaad.2023.07.1011. Epub 2023 Jul 24.
Central centrifugal cicatricial alopecia (CCCA) is a scarring alopecia seen primarily in women of African descent but rarely reported in men. The etiology of CCCA is unknown, but genetic variants, type 2 diabetes mellitus, and bacterial infections may play a role.
We aimed to characterize the demographics, medical histories, and clinical findings of male patients with CCCA with the hypothesis that features may differ from women.
This was a case series of adult male patients with biopsy-confirmed CCCA seen at an academic dermatology department between 2012 and 2022.
In total, 17 males had a scalp biopsy and clinical findings consistent with CCCA. The average age was 43 years, and 88.2% of cases identified as Black race. Scalp pruritus was the most common symptom, and few patients endorsed high-risk hair care practices. None of the cases had diagnosis of type 2 diabetes mellitus, but 17.6% had history of latent tuberculosis, and 47.1% had a positive family history of alopecia. We observed 8 patients with atypical CCCA, and 29.4% had an overlapping scalp diagnosis.
This study is limited by the single center, retrospective design and small sample size.
It is important to consider CCCA in the differential diagnosis of alopecia in adult Black males.
中心离心性瘢痕性秃发（CCCA）是一种瘢痕性秃发，主要见于非洲裔女性，但男性中鲜有报道。CCCA的病因尚不清楚，但基因变异、2型糖尿病和细菌感染可能起一定作用。
我们旨在描述CCCA男性患者的人口统计学特征、病史和临床发现，假设其特征可能与女性不同。
这是一个病例系列，纳入了2012年至2022年在一家学术皮肤科就诊的经活检确诊为CCCA的成年男性患者。
共有17名男性进行了头皮活检，临床发现与CCCA一致。平均年龄为43岁，88.2%的病例为黑人。头皮瘙痒是最常见的症状，很少有患者认可高风险的头发护理习惯。所有病例均未诊断为2型糖尿病，但17.6%有潜伏性结核病史，47.1%有秃发家族史阳性。我们观察到8例非典型CCCA患者，29.4%有重叠的头皮诊断。
本研究受单中心、回顾性设计和样本量小的限制。
在成年黑人男性秃发的鉴别诊断中考虑CCCA很重要。
