Assistant Professor, College of Nursing, Jeonbuk National University, and Reseach Institute of Nursing Science, Jeonbuk National University, Jeonju-si, Republic of Korea.
Assistant Professor, University of Rhode Island College of Nursing, Kingston, Rhode Island, USA.
Semin Oncol Nurs. 2023 Oct;39(5):151477. doi: 10.1016/j.soncn.2023.151477. Epub 2023 Jul 24.
This study aimed to review dyadic research on psychological health and health-related quality of life (HRQL) in patients with colorectal cancer (CRC) and caregivers and examine the pooled partner effects and actor effects based on the Actor-Partner Interdependence Model.
A systematic review and meta-analysis were conducted. We registered our review protocol with PROSPERO (CRD42021258482). Six databases were searched until June 2021 using the following keywords: colorectal neoplasms, caregivers, depression, anxiety, stress, and quality of life. Two reviewers independently screened 1,597 studies that included both CRC patients and family caregivers. Meta-analyses were performed of the partner and actor effects of psychological health on HRQL in CRC.
Eighteen observational studies involving 2,757 patients with CRC and 2,601 caregivers were included. Regarding partner effects, the distress of patients with CRC affected their family caregivers' distress and burden. There were three types of actor effects among patients with CRC and family caregivers: 1) the social support of patients with CRC affects their level of distress; (2) the distress of patients with CRC affects their HRQL; and (3) caregivers' social support affects their level of distress. This study provides the first comprehensive overview of the dyadic relationships between psychological health and HRQL in patients with CRC and their caregivers.
The development of dyadic interventions for improving psychological health is warranted to help both patients with CRC and their family caregivers live with improved HRQL and well-being.
本研究旨在回顾关于结直肠癌（CRC）患者及其照顾者的心理健康和健康相关生活质量（HRQL）的对偶研究，并根据主体间相互依赖模型检验汇总的伴侣效应和主体效应。
进行了系统评价和荟萃分析。我们在 PROSPERO（CRD42021258482）上注册了我们的综述方案。使用以下关键词在 2021 年 6 月之前在六个数据库中搜索了包括 CRC 患者和家庭照顾者的 1597 项研究：结直肠肿瘤，照顾者，抑郁，焦虑，压力和生活质量。两位审阅者独立筛选了包括 2757 名 CRC 患者和 2601 名照顾者的 18 项观察性研究。对 CRC 中心理健康对 HRQL 的伴侣和主体效应进行了荟萃分析。
纳入了 18 项涉及 2757 名 CRC 患者和 2601 名照顾者的观察性研究。关于伴侣效应，CRC 患者的痛苦会影响其家庭照顾者的痛苦和负担。CRC 患者和家庭照顾者中有三种主体效应：1）CRC 患者的社会支持会影响其痛苦程度；2）CRC 患者的痛苦会影响其 HRQL；3）照顾者的社会支持会影响其痛苦程度。本研究首次全面概述了 CRC 患者及其照顾者之间心理健康和 HRQL 的对偶关系。
有必要制定对偶干预措施来改善心理健康，以帮助 CRC 患者及其家庭照顾者提高 HRQL 和幸福感。
