Janda A, Salem C
Reg Anaesth. 1986 Jul;9(3):88-90.
Hypoglycaemia with manifest clinical symptoms has been observed in four patients with cardiac insufficiency after infiltration of high doses of lidocaine prior to surgery. The depressing influence of lidocaine on blood glucose levels has also been seen in six out of 12 patients to whom a pacemaker was implanted in local anaesthesia. The interaction between hepatic glucose- and lidocaine-metabolism could possibly be responsible for this effect. Therefore the evaluation of blood glucose level and iv. administration of glucose is advisable in patients with systemic toxic reactions following lidocaine overdosage to avoid unnecessary symptomatic therapy.
在4例心脏功能不全患者术前高剂量利多卡因浸润后，观察到有明显临床症状的低血糖。在12例局部麻醉下植入起搏器的患者中，也有6例出现利多卡因对血糖水平的抑制作用。肝葡萄糖代谢与利多卡因代谢之间的相互作用可能是造成这种影响的原因。因此，利多卡因过量导致全身毒性反应的患者，建议评估血糖水平并静脉注射葡萄糖，以避免不必要的对症治疗。
