Department of Reproductive Health and Midwifery, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, 14115-111, Iran.
Department of Midwifery, School of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Sci Rep. 2023 Jul 26;13(1):12083. doi: 10.1038/s41598-023-39341-w.
Recent evidence suggests that vitamin D deficiency could play an important role in the development of non-skeletal diseases, including cancer. Vitamin D also affects the function of the reproductive system. In the present study, the relationship between 25(OH)D levels with oocyte quality in Breast Cancer (BC) women and control group have been investigated. After initial evaluations, ovarian stimulation began with the GnRH antagonist protocol in the BC group (N = 16) and control group (N = 16). The serum and follicular fluid (FF) 25(OH)D levels were measured at the time of oocyte retrieval and their relationship to oocyte quality was examined. The mean levels of serum and FF 25(OH)D in BC women were significantly lower than in the control group (22.26 ± 7.98 vs. 29.61 ± 9.12, P = 0.02, 21.65 ± 7.59 vs. 28.00 ± 9.05, P = 0.04, respectively). There was a significant correlation between the levels of 25(OH)D in FF and serum in BC women (r = 0.873, P < 0.001). But there was no correlation between the serum or FF 25(OH)D levels with the parameters related to oocytes (P > 0.05). In the BC women, the number of dysmorph and highly dysmorph oocytes was higher than in the control group (P < 0.001). Women with BC referring to infertility centers for fertility preservation are more likely to be deficient in serum 25(OH)D level; this subsequently affects the FF 25(OH)D level. However, serum and FF 25(OH)D levels may not be suitable indicators for examining maturity and quality of oocytes in terms of morphology in BC women, and the poor morphological quality of oocytes in BC women may be due to other factors.
最近的证据表明，维生素 D 缺乏可能在非骨骼疾病（包括癌症）的发展中发挥重要作用。维生素 D 还影响生殖系统的功能。在本研究中，研究了乳腺癌（BC）妇女和对照组的血清 25（OH）D 水平与卵母细胞质量之间的关系。经过初步评估，BC 组（N=16）和对照组（N=16）开始使用 GnRH 拮抗剂方案进行卵巢刺激。在卵母细胞采集时测量血清和卵泡液（FF）25（OH）D 水平，并检查其与卵母细胞质量的关系。BC 妇女的血清和 FF 25（OH）D 平均水平明显低于对照组（22.26±7.98 与 29.61±9.12，P=0.02，21.65±7.59 与 28.00±9.05，P=0.04）。BC 妇女的 FF 和血清 25（OH）D 水平之间存在显著相关性（r=0.873，P<0.001）。但是，血清或 FF 25（OH）D 水平与卵母细胞相关参数之间没有相关性（P>0.05）。在 BC 妇女中，畸形和高度畸形卵母细胞的数量高于对照组（P<0.001）。因生育保存而到不孕不育中心就诊的 BC 妇女更有可能缺乏血清 25（OH）D 水平；这随后会影响 FF 25（OH）D 水平。然而，血清和 FF 25（OH）D 水平可能不是 BC 妇女卵母细胞成熟和质量的合适指标，BC 妇女卵母细胞形态较差可能是由于其他因素。
