Barrett G L, Packer J S, Davis J M
Ren Physiol. 1986;9(4):223-40. doi: 10.1159/000173087.
A dynamic rat renal medullary model was employed to study how independent control of excretion of various substances is achieved. Salt and water reabsorptive coupling was heterogeneous in the distal nephron. Diversion of filtrate to juxtamedullary nephrons retained salt with little effect on water or urea, a response enhanced by concomitant reduction in inner medullary blood flow. Urine concentration required high permeability and low flow in medullary blood vessels and active inner medullary salt transport. Collecting duct urea movement was closely coupled to that of water and urea recycling was enhanced by incorporation of nephrovascular bundles.
采用动态大鼠肾髓质模型来研究如何实现对各种物质排泄的独立控制。远端肾单位中盐和水重吸收的耦合是不均匀的。将滤液分流至近髓肾单位可保留盐分，对水或尿素影响较小，髓质内血流同时减少可增强这种反应。尿液浓缩需要髓质血管具有高通透性和低流量，以及髓质内盐的主动转运。集合管尿素的移动与水的移动密切相关，并且通过并入肾血管束可增强尿素的再循环。
