不同型号Amplatzer封堵器及类似封堵器治疗卵圆孔未闭的短期疗效比较
Comparison of the short-term efficacy of different Amplatzer models and similar occluders in the treatment of patent foramen ovale.
作者信息
Lou Yuxuan, Hua Yang, Shi Jing, Yang Fengze, Wang Yifei, Yang Yang, Sun Wei, Kong Xiangqing, Zhang Hao
机构信息
Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Southeast University School of Medicine, Nanjing, China.
出版信息
Front Cardiovasc Med. 2023 Jul 11;10:1092465. doi: 10.3389/fcvm.2023.1092465. eCollection 2023.
OBJECTIVE
To compare the recent efficacy and safety of different Amplatzer models and similar occluder in the treatment of patent foramen ovale (PFO).
METHODS
Patients with PFO complicated with cryptogenic stroke or migraine who underwent transcatheter closure of PFO in the First Affiliated Hospital of Nanjing Medical University from September 2019 to March 2021 were selected. Patients were grouped according to the type of occluder device. The basic data of the patients were collected and followed up within 1 year after occlusion. Effectiveness was defined as no recurrence of stroke/remission of migraine symptoms and a negative postoperative foaming test, and safety events were counted as the combined results of serious adverse events.
RESULTS
A total of 92 patients were selected, including 45 cases in the symmetrical group and 47 cases in the asymmetric group. There were no serious adverse events in the 2 groups during follow-up. 3 days and 1 month after occlusion, the number of shunt patients in the asymmetric group was significantly less than that in the symmetric group ( = 5.484, = 0.019; = 5.146, = 0.023). The negative rate of blocked residual shunts in the asymmetric group was higher than that in the symmetric group at 1, 3, 6 and 12 months after occlusion ( = 6.473, = 0.011; = 4.305, = 0.038; = 4.842, = 0.027; = 4.034, = 0.045). Headache in migraine patients in the asymmetric group was significantly better than headache in patients in the symmetric group ( = 0.038; = 0.049).
CONCLUSION
Asymmetric Amplatzer and similar occluders provide greater efficacy in short-term occlusion than symmetric ones.
目的
比较不同型号Amplatzer封堵器及类似封堵器治疗卵圆孔未闭（PFO）的近期疗效及安全性。
方法
选取2019年9月至2021年3月在南京医科大学第一附属医院行经导管封堵PFO治疗的合并不明原因卒中或偏头痛的PFO患者。根据封堵器类型对患者进行分组。收集患者的基本资料并在封堵术后1年内进行随访。疗效定义为无卒中复发/偏头痛症状缓解且术后发泡试验阴性，安全事件计为严重不良事件的合并结果。
结果
共入选92例患者，其中对称组45例，不对称组47例。随访期间两组均未发生严重不良事件。封堵术后3天及1个月，不对称组分流患者数量显著少于对称组（χ² = 5.484，P = 0.019；χ² = 5.146，P = 0.023）。封堵术后1、3、6和12个月，不对称组封堵残余分流阴性率高于对称组（χ² = 6.473，P = 0.011；χ² = 4.305，P = 0.038；χ² = 4.842，P = 0.027；χ² = 4.034，P = 0.045）。不对称组偏头痛患者的头痛症状明显优于对称组患者（P = 0.038；P = 0.049）。
结论
不对称型Amplatzer封堵器及类似封堵器在短期封堵中比对称型封堵器疗效更佳。
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