Derakhshan R, Ahmadian M T, Chizari M, Samimiardestani H
School of Mechanical Engineering, Sharif University of Technology, Tehran, Iran.
School of Mechanical Engineering, Sharif University of Technology, Center of Excellence in Design, Robotic and Automation, Tehran, Iran.
Heliyon. 2023 Jul 8;9(7):e17872. doi: 10.1016/j.heliyon.2023.e17872. eCollection 2023 Jul.
The spinal cord is a structure of nervous tissue that primarily transmits nerve signals from the motor cortex to the body and from the afferent fibers of the sensory neurons to the sensory cortex. It is enveloped by three layers of meninges. Covering provides a supportive framework for the cerebral and cranial vasculature and protects the central nervous system (CNS) from mechanical damage. Surgical operation in the vicinity of the spinal cord is complicated and risky because it exposes it to probably irreversible damage. To reduce the risk of these operations, attempts have been made to remove the tumor using safer methods like waterjet operation. In these methods, the waterjet and spinal cord interaction are inevitable. To secure interaction of operation, a standard development of waterjet criteria is necessary. In this study, a system of waterjet is designed to perform sheep spinal cord as a tissue with a good resemblance to the human spinal cord. Effects of interaction between waterjet and sheep spinal cord are investigated to define a safe operation threshold. The impact of the liquid density of waterjet on failure criteria of spinal cord surgery is also investigated. Results show that meninges are stiff enough to protect the sheep spinal cord from rupture for pressures up to 8 bar; however internal spinal cord tissue cannot be guaranteed any damage. Three essential parameters represent the spinal cord meninges and spinal cord deformation during the tests. These parameters lead us to provide standard criteria for damage prevention of the spinal cord.
脊髓是神经组织的一种结构,主要将神经信号从运动皮层传递到身体,并从感觉神经元的传入纤维传递到感觉皮层。它被三层脑膜所包裹。这些覆盖物为大脑和颅部血管系统提供了一个支持框架,并保护中枢神经系统(CNS)免受机械损伤。在脊髓附近进行手术复杂且有风险,因为这可能会使其遭受不可逆的损伤。为降低这些手术的风险,人们尝试使用诸如水刀手术等更安全的方法来切除肿瘤。在这些方法中,水刀与脊髓的相互作用是不可避免的。为确保手术的相互作用,有必要制定水刀标准的规范。在本研究中,设计了一种水刀系统,以绵羊脊髓作为与人类脊髓高度相似的组织进行实验。研究水刀与绵羊脊髓之间相互作用的影响,以确定安全的手术阈值。还研究了水刀液体密度对脊髓手术失败标准的影响。结果表明,脑膜足够坚韧,在压力高达8巴时能保护绵羊脊髓不破裂;然而,无法保证脊髓内部组织不受任何损伤。三个关键参数代表了测试过程中脊髓脑膜和脊髓的变形情况。这些参数使我们能够为预防脊髓损伤提供标准规范。