Department of Anesthesiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Institute of Anesthesia and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Int J Biol Sci. 2023 Jul 3;19(11):3472-3482. doi: 10.7150/ijbs.84353. eCollection 2023.
Pain, one of the most important problems in the field of medicine and public health, has great research significance. Opioids are still the main drugs to relieve pain now. However, its application is limited due to its obvious side effects. Therefore, it is urgent to develop new drugs to relieve pain. Multiple studies have found that IGF/IGF-1R pathway plays an important role in the occurrence and development of pain. The regulation of IGF/IGF-1R pathway has obvious effect on pain. This review summarized and discussed the therapeutic potential of IGF/IGF-1R signal pathway for pain. It also summarized that IGF/IGF-1R regulates pain by acting on neuronal excitability, neuroinflammation, glial cells, apoptosis, etc. However, its mechanisms of occurrence and development in pain still need further study in the future. In conclusion, although more deep researches are needed, these studies indicate that IGF/IGF-1R signal pathway is a promising therapeutic target for pain.
疼痛是医学和公共卫生领域最重要的问题之一，具有重要的研究意义。阿片类药物仍然是缓解疼痛的主要药物。然而，由于其明显的副作用，其应用受到限制。因此，迫切需要开发新的止痛药。多项研究发现，IGF/IGF-1R 通路在疼痛的发生和发展中起重要作用。IGF/IGF-1R 通路的调节对疼痛有明显的效果。本综述总结并讨论了 IGF/IGF-1R 信号通路治疗疼痛的潜力。也总结了 IGF/IGF-1R 通过作用于神经元兴奋性、神经炎症、神经胶质细胞、细胞凋亡等调节疼痛。然而，其在疼痛中的发生和发展机制仍需要进一步研究。总之，尽管还需要更深入的研究，但这些研究表明 IGF/IGF-1R 信号通路是治疗疼痛的一个有前途的靶点。
